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HomoloGene:3855. Gene conserved in Euteleostomi Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

GFRA1,  H.sapiens
GDNF family receptor alpha 1
465 aa
GFRA1,  P.troglodytes
GDNF family receptor alpha 1
467 aa
GFRA1,  C.lupus
GDNF family receptor alpha 1
468 aa
GFRA1,  B.taurus
GDNF family receptor alpha 1
456 aa
Gfra1,  M.musculus
glial cell line derived neurotrophic factor family receptor alpha 1
468 aa
Gfra1,  R.norvegicus
GDNF family receptor alpha 1
468 aa
GFRA1,  G.gallus
GDNF family receptor alpha 1
469 aa
gfra1,  X.tropicalis
GDNF family receptor alpha 1
460 aa
gfra1a,  D.rerio
gdnf family receptor alpha 1a
472 aa
gfra1b,  D.rerio
gdnf family receptor alpha 1b
481 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Articles associated with genes and sequences of this homology group.

GFR α-1 receptor expression in the aging nigrostriatal and mesoaccumbens pathways.
Pruett BS & Salvatore MF. J Neurochem 115, 707-15 (2010).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
GDNF (pfam02351)
  GDNF/GAS1 domain.
GDNF (cl19746)
  This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Gfra1 includes H.sapiens GFRA1 and R.norvegicus Gfra1.




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