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HomoloGene:36201. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

SEMA3C,  H.sapiens
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
NP_006370.1
751 aa
SEMA3C,  P.troglodytes
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
XP_001159729.2
769 aa
SEMA3C,  M.mulatta
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
XP_001108385.1
751 aa
SEMA3C,  C.lupus
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
XP_533139.2
750 aa
SEMA3C,  B.taurus
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
NP_001094552.1
751 aa
Sema3c,  M.musculus
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
NP_038685.3
751 aa
Sema3c,  R.norvegicus
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
NP_001100048.1
751 aa
SEMA3C,  G.gallus
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
NP_989574.1
751 aa
sema3c,  X.tropicalis
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
XP_002933132.1
748 aa
sema3c,  D.rerio
semaphorin 3c
XP_692847.3
756 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Semaphorin 3C is involved in the progression of gastric cancer.
Miyato H, et al. Cancer Sci 103, 1961-6 (2012).
Identification of semaphorin E as a non-MDR drug resistance gene of human cancers.
Yamada T, et al. Proc Natl Acad Sci U S A 94, 14713-8 (1997).
Integration of opposing semaphorin guidance cues in cortical axons.
Ruediger T, et al. Cereb Cortex 23, 604-14 (2013).
The cleavage of semaphorin 3C induced by ADAMTS1 promotes cell migration.
Esselens C, et al. J Biol Chem 285, 2463-73 (2010).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
PSI (cl02601)
  A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas shows 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).
Ig (cl11960)
  Immunoglobulin domain.
Sema (cl15693)
  The Sema domain, a protein interacting module, of semaphorins and plexins.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Sema3c includes H.sapiens SEMA3C and R.norvegicus Sema3c.


 

 

 

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