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HomoloGene:3468. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

ARHGEF2,  H.sapiens
Rho/Rac guanine nucleotide exchange factor (GEF) 2
NP_001155855.1
986 aa
ARHGEF2,  P.troglodytes
Rho/Rac guanine nucleotide exchange factor (GEF) 2
XP_003308546.1
985 aa
ARHGEF2,  M.mulatta
Rho/Rac guanine nucleotide exchange factor (GEF) 2
XP_002801891.1
985 aa
ARHGEF2,  C.lupus
Rho/Rac guanine nucleotide exchange factor (GEF) 2
NP_001002995.1
986 aa
ARHGEF2,  B.taurus
Rho/Rac guanine nucleotide exchange factor (GEF) 2
NP_001092351.2
987 aa
Arhgef2,  M.musculus
rho/rac guanine nucleotide exchange factor (GEF) 2
NP_032513.3
985 aa
Arhgef2,  R.norvegicus
rho/rac guanine nucleotide exchange factor (GEF) 2
NP_001012079.1
985 aa
arhgef2,  X.tropicalis
Rho/Rac guanine nucleotide exchange factor (GEF) 2
NP_001001456.1
978 aa
arhgef2,  D.rerio
rho/rac guanine nucleotide exchange factor (GEF) 2
XP_689770.5
872 aa
arhgef1a,  D.rerio
Rho guanine nucleotide exchange factor (GEF) 1a
NP_001075100.1
935 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Changes in the GEF-H1 pathways after traumatic brain injury.
Sabirzhanova I, et al. J Neurotrauma 30, 1449-56 (2013).
Mechanotransduction by GEF-H1 as a novel mechanism of ventilator-induced vascular endothelial permeability.
Birukova AA, et al. Am J Physiol Lung Cell Mol Physiol 298, L837-48 (2010).
The Rho GTP exchange factor Lfc promotes spindle assembly in early mitosis.
Bakal CJ, et al. Proc Natl Acad Sci U S A 102, 9529-34 (2005).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
PH (pfam00169)
  PH domain.
C1 (cl00040)
  Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
RhoGEF (cl02571)
  Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
CdhC (cl11685)
  CO dehydrogenase/acetyl-CoA synthase complex beta subunit.
PH-like (cl17171)
  Pleckstrin homology-like domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Arhgef2 includes H.sapiens ARHGEF2 and R.norvegicus Arhgef2.


 

 

 

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