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HomoloGene:3144. Gene conserved in Euteleostomi Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

RECQL4,  H.sapiens
RecQ protein-like 4
1208 aa
RECQL4,  P.troglodytes
RecQ protein-like 4
1208 aa
RECQL4,  C.lupus
RecQ protein-like 4
1109 aa
RECQL4,  B.taurus
RecQ protein-like 4
1218 aa
Recql4,  M.musculus
RecQ protein-like 4
1216 aa
Recql4,  R.norvegicus
RecQ protein-like 4
1216 aa
recql4,  X.tropicalis
RecQ protein-like 4
1520 aa
LOC567383,  D.rerio
ATP-dependent DNA helicase Q4-like
1459 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Phenotypic information for the genes in this entry imported from model organism databases.

Baller-Gerold syndrome.
RAPADILINO syndrome.
Rothmund-Thomson syndrome.

Articles associated with genes and sequences of this homology group.

RECQL4 in genomic instability and aging.
Croteau DL, et al. Trends Genet 28, 624-31 (2012).
RAPADILINO RECQL4 mutant protein lacks helicase and ATPase activity.
Croteau DL, et al. Biochim Biophys Acta 1822, 1727-34 (2012).
The N-terminus of the human RecQL4 helicase is a homeodomain-like DNA interaction motif.
Ohlenschläger O, et al. Nucleic Acids Res 40, 8309-24 (2012).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
zf-CCHC (cl15298)
  Zinc knuckle.
DEXDc (smart00487)
  DEAD-like helicases superfamily.
Drc1-Sld2 (pfam11719)
  DNA replication and checkpoint protein.
HELICc (cd00079)
  Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
DEXDc (cl17251)
  DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Recql4 includes H.sapiens RECQL4 and R.norvegicus Recql4.




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