HomoloGene - NCBI

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HomoloGene:30992. Gene conserved in Euteleostomi

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Genes Genes identified as putative homologs of one another during the construction of HomoloGene.			Proteins Proteins used in sequence comparisons and their conserved domain architectures.
	DRD1, H.sapiens dopamine receptor D1			NP_000785.1 446 aa
	DRD1, P.troglodytes dopamine receptor D1			XP_001149473.2 446 aa
	DRD1, C.lupus dopamine receptor D1			XP_005619252.1 446 aa
	DRD1, B.taurus dopamine receptor D1			NP_776467.1 446 aa
	Drd1a, M.musculus dopamine receptor D1A			NP_034206.1 446 aa
	Drd1, R.norvegicus dopamine receptor D1			NP_036678.2 446 aa
	DRD1, G.gallus dopamine receptor D1			NP_001138320.1 451 aa
	drd1, X.tropicalis dopamine receptor D1			XP_004912926.1 451 aa
	drd1b, D.rerio dopamine receptor D1b			NP_001129448.1 446 aa

Protein Alignments

Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST

Regenerate Alignments

Publications Articles associated with genes and sequences of this homology group.
Nonlinear dose-dependent impact of D1 receptor activation on motor cortex plasticity in humans. Fresnoza S, et al. J Neurosci 34, 2744-53 (2014).
Medial prefrontal D1 dopamine neurons control food intake. Land BB, et al. Nat Neurosci 17, 248-53 (2014).
Phenotyping dividing cells in mouse models of neurodegenerative basal ganglia diseases. Smardencas A, et al. BMC Neurosci 14, 111 (2013).
Dopamine receptors and the pharmacogenetics of side-effects of stimulant treatment for attention-deficit/hyperactivity disorder. Levy F, et al. J Child Adolesc Psychopharmacol 23, 423-5 (2013).
Transcription factor Nrf2 protects renal dopamine D1 receptor function during oxidative stress. Banday AA & Lokhandwala MF. Hypertension 62, 512-7 (2013).
Mesoaccumbens dopamine signaling alteration underlies behavioral transition from tolerance to sensitization to morphine rewarding properties during morphine withdrawal. Sun L, et al. Brain Struct Funct 219, 1755-71 (2014).
Human kidney-2 cells harbor functional dopamine D1 receptors that require Giα for Gq/11α signaling. Pokkunuri ID, et al. Am J Physiol Renal Physiol 305, F560-7 (2013).
Genetic reconstruction of dopamine D1 receptor signaling in the nucleus accumbens facilitates natural and drug reward responses. Gore BB & Zweifel LS. J Neurosci 33, 8640-9 (2013).
Dopamine D1 receptors are not critical for opiate reward but can mediate opiate memory retrieval in a state-dependent manner. Ting-A-Kee R, et al. Behav Brain Res 247, 174-177 (2013).
Rewarding effects of ethanol combined with low doses of morphine through dopamine D1 receptors. Ise Y, et al. J Nippon Med Sch 80, 34-41 (2013).
See all (636)

Conserved Domains Conserved Domains from CDD found in protein sequences by rpsblast searching.
7tm_4 (cl10458) Olfactory receptor.
7TM_GPCR_Srx (pfam10328) Serpentine type 7TM GPCR chemoreceptor Srx.
7tm_1 (pfam00001) 7 transmembrane receptor (rhodopsin family).

Related Homology Resources Links to curated and computed homology information found in other databases.
MGI:99578 Orthology group for M.musculus Drd1a includes H.sapiens DRD1 and R.norvegicus Drd1a.

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