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HomoloGene:2554. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

XPO1,  H.sapiens
exportin 1
NP_003391.1
1071 aa
XPO1,  P.troglodytes
exportin 1 (CRM1 homolog, yeast)
XP_515727.2
1071 aa
XPO1,  M.mulatta
exportin 1 (CRM1 homolog, yeast)
XP_001115623.1
1071 aa
XPO1,  C.lupus
exportin 1 (CRM1 homolog, yeast)
XP_005626195.1
1071 aa
XPO1,  B.taurus
exportin 1 (CRM1 homolog, yeast)
NP_001179190.1
1071 aa
Xpo1,  M.musculus
exportin 1, CRM1 homolog (yeast)
NP_001030303.1
1071 aa
Xpo1,  R.norvegicus
exportin 1, CRM1 homolog (yeast)
NP_445942.1
1071 aa
XPO1,  G.gallus
exportin 1 (CRM1 homolog, yeast)
NP_001012887.2
1071 aa
xpo1,  X.tropicalis
exportin 1 (CRM1 homolog)
XP_002939551.2
1071 aa
xpo1b,  D.rerio
exportin 1 (CRM1 homolog, yeast) b
XP_001919797.3
1074 aa
emb,  D.melanogaster
embargoed
NP_723391.2
1063 aa
AgaP_AGAP009929,  A.gambiae
AgaP_AGAP009929
XP_319051.2
1053 aa
xpo-1,  C.elegans
xpo-1
NP_741567.1
1080 aa
CRM1,  S.cerevisiae
CRM1
NP_011734.3
1084 aa
KLLA0E16061g,  K.lactis
KLLA0E16061g
XP_454672.1
1086 aa
AGOS_ADL128C,  E.gossypii
AGOS_ADL128C
NP_983968.2
1082 aa
crm1,  S.pombe
crm1
XP_001713070.1
1078 aa
MGG_02526,  M.oryzae
MGG_02526
XP_003709336.1
1081 aa
NCU01820,  N.crassa
NCU01820
XP_955917.2
1078 aa
XPO1B,  A.thaliana
XPO1B
NP_566193.2
1076 aa
XPO1A,  A.thaliana
XPO1A
NP_197204.1
1075 aa
Os03g0858100,  O.sativa
Os03g0858100
NP_001051959.1
1070 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Structural determinants and mechanism of mammalian CRM1 allostery.
Dölker N, et al. Structure 21, 1350-60 (2013).
Structural basis for cooperativity of CRM1 export complex formation.
Monecke T, et al. Proc Natl Acad Sci U S A 110, 960-5 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Xpo1 (pfam08389)
  Exportin 1-like protein.
Xpo1 (pfam08389)
  Exportin 1-like protein.
IBN_N (cl04271)
  Members of the importin-beta (karyopherin-beta) family can bind and transport cargo by themselves, or can form heterodimers with importin-alpha. As part of a heterodimer, importin-beta mediates interactions with the pore complex, while importin-alpha acts as an adaptor protein to bind the nuclear localisation signal (NLS) on the cargo through the classical NLS import of proteins. Importin-beta is a helicoidal molecule constructed from 19 HEAT repeats. Many nuclear pore proteins contain FG sequence repeats that can bind to HEAT repeats within importins.. which is important for importin-beta mediated transport.
CRM1_C (cl07396)
  CRM1 (also known as Exportin1) mediates the nuclear export of proteins bearing a leucine-rich nuclear export signal (NES). CRM1 forms a complex with the NES containing protein and the small GTPase Ran. This region forms an alpha helical structure formed by six helical hairpin motifs that are structurally similar to the HEAT repeat, but share little sequence similarity to the HEAT repeat.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Xpo1 includes H.sapiens XPO1 and R.norvegicus Xpo1.


 

 

 

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