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HomoloGene:23741. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

HMCN1,  H.sapiens
hemicentin 1
NP_114141.2
5635 aa
HMCN1,  P.troglodytes
hemicentin 1
XP_514061.2
5635 aa
HMCN1,  C.lupus
hemicentin 1
XP_547438.2
5637 aa
HMCN1,  B.taurus
hemicentin 1
NP_001179466.1
5635 aa
Hmcn1,  M.musculus
hemicentin 1
NP_001019891.2
5634 aa
Hmcn1,  R.norvegicus
hemicentin 1
NP_001258221.1
5635 aa
HMCN1,  G.gallus
hemicentin 1
XP_003643223.1
5635 aa
hmcn1,  D.rerio
hemicentin 1
NP_001177233.1
5615 aa
AgaP_AGAP002268,  A.gambiae
AgaP_AGAP002268
XP_001687828.2
2743 aa
him-4,  C.elegans
him-4
NP_001129925.1
5213 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Macular degeneration, age-related, 1.
Posterior column ataxia with retinitis pigmentosa.



Publications
Articles associated with genes and sequences of this homology group.

Distinct regions within fibulin-1D modulate interactions with hemicentin.
Muriel JM, et al. Exp Cell Res 318, 2543-7 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
I-set (pfam07679)
  Immunoglobulin I-set domain.
IGc2 (smart00408)
  Immunoglobulin C-2 Type.
IG (smart00409)
  Immunoglobulin.
IG_like (smart00410)
  Immunoglobulin like.
MD (smart00604)
  MD domain.
nidG2 (cd00255)
  Nidogen, G2 domain; Nidogen is an important component of the basement membrane, an extracellular sheet-like matrix. Nidogen is a multifunctional protein that interacts with many other basement membrane proteins, like collagen, perlecan, lamin, and has a ...
Ig (cl11960)
  Immunoglobulin domain.
I-set (pfam07679)
  Immunoglobulin I-set domain.
vWFA (cl00057)
  Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
EGF_CA (cl09941)
  Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
Ig (cl11960)
  Immunoglobulin domain.
TSP_1 (cl15278)
  Thrombospondin type 1 domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Hmcn1 includes H.sapiens HMCN1.


 

 

 

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