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HomoloGene:2302. Gene conserved in Euteleostomi Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

SLIT1,  H.sapiens
slit homolog 1 (Drosophila)
1534 aa
SLIT1,  P.troglodytes
slit homolog 1 (Drosophila)
1672 aa
SLIT1,  M.mulatta
slit homolog 1 (Drosophila)
1702 aa
SLIT1,  C.lupus
slit homolog 1 (Drosophila)
1534 aa
SLIT1,  B.taurus
slit homolog 1 (Drosophila)
1534 aa
Slit1,  M.musculus
slit homolog 1 (Drosophila)
1531 aa
Slit1,  R.norvegicus
slit homolog 1 (Drosophila)
1531 aa
SLIT1,  G.gallus
slit homolog 1 (Drosophila)
1544 aa
slit1,  X.tropicalis
slit homolog 1
1529 aa
slit1a,  D.rerio
slit homolog 1a (Drosophila)
1524 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Articles associated with genes and sequences of this homology group.

Two divergent slit1 genes in zebrafish.
Hutson LD, et al. Dev Dyn 228, 358-69 (2003).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
LRR_4 (pfam12799)
  Leucine Rich repeats (2 copies).
LRR_8 (pfam13855)
  Leucine rich repeat.
LRRCT (smart00082)
  Leucine rich repeat C-terminal domain.
LRRNT (cl02423)
  Leucine rich repeat N-terminal domain.
LRR_4 (pfam12799)
  Leucine Rich repeats (2 copies).
LRR_8 (pfam13855)
  Leucine rich repeat.
EGF_CA (cl09941)
  Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
LamG (cl17353)
  Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
DAN (cl17734)
  DAN domain.

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Slit1 includes H.sapiens SLIT1 and R.norvegicus Slit1.




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