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HomoloGene:11102. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

MTBP,  H.sapiens
MDM2 binding protein
NP_071328.2
904 aa
MTBP,  P.troglodytes
Mdm2, transformed 3T3 cell double minute 2, p53 binding protein (mouse) binding protein, 104kDa
XP_519930.2
904 aa
MTBP,  M.mulatta
Mdm2, transformed 3T3 cell double minute 2, p53 binding protein (mouse) binding protein, 104kDa
XP_001098134.1
904 aa
MTBP,  C.lupus
Mdm2, transformed 3T3 cell double minute 2, p53 binding protein (mouse) binding protein, 104kDa
XP_851376.1
899 aa
MTBP,  B.taurus
Mdm2, transformed 3T3 cell double minute 2, p53 binding protein (mouse) binding protein, 104kDa
NP_001180106.1
898 aa
Mtbp,  M.musculus
Mdm2, transformed 3T3 cell double minute p53 binding protein
NP_598853.3
894 aa
Mtbp,  R.norvegicus
Mdm2, transformed 3T3 cell double minute 2, p53 binding protein (mouse) binding protein
NP_001124189.1
894 aa
MTBP,  G.gallus
Mdm2, transformed 3T3 cell double minute 2, p53 binding protein (mouse) binding protein, 104kDa
XP_418460.4
919 aa
mtbp,  X.tropicalis
Mdm2, transformed 3T3 cell double minute 2, p53 binding protein binding protein, 104kDa
NP_001107690.1
867 aa
LOC100534898,  D.rerio
mdm2-binding protein-like
XP_003200205.1
845 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

MDM2 binding protein, a novel metastasis suppressor.
Iwakuma T & Agarwal N. Cancer Metastasis Rev 31, 633-40 (2012).
MTBP plays a crucial role in mitotic progression and chromosome segregation.
Agarwal N, et al. Cell Death Differ 18, 1208-19 (2011).
Mtbp haploinsufficiency in mice increases tumor metastasis.
Iwakuma T, et al. Oncogene 27, 1813-20 (2008).
Regulation of p53 and MDM2 activity by MTBP.
Brady M, et al. Mol Cell Biol 25, 545-53 (2005).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
SelB-wing_3 (pfam09107)
  Elongation factor SelB, winged helix.
MTBP_N (pfam14918)
  MDM2-binding.
MTBP_mid (pfam14919)
  MDM2-binding.
MTBP_C (pfam14920)
  MDM2-binding.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Mtbp includes H.sapiens MTBP.


 

 

 

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