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HomoloGene:96. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

ERCC3,  H.sapiens
excision repair cross-complementation group 3
NP_000113.1
782 aa
ERCC3,  P.troglodytes
excision repair cross-complementing rodent repair deficiency, complementation group 3
XP_525907.3
768 aa
ERCC3,  M.mulatta
excision repair cross-complementing rodent repair deficiency, complementation group 3
XP_001086722.1
782 aa
ERCC3,  C.lupus
excision repair cross-complementing rodent repair deficiency, complementation group 3
XP_533314.2
782 aa
ERCC3,  B.taurus
excision repair cross-complementing rodent repair deficiency, complementation group 3 (xeroderma pigmentosum group B complementing)
NP_001039453.1
782 aa
Ercc3,  M.musculus
excision repair cross-complementing rodent repair deficiency, complementation group 3
NP_598419.1
783 aa
Ercc3,  R.norvegicus
excision repair cross-complementing rodent repair deficiency, complementation group 3
NP_001026814.1
782 aa
ERCC3,  G.gallus
excision repair cross-complementing rodent repair deficiency, complementation group 3
NP_001006523.1
788 aa
ercc3,  X.tropicalis
excision repair cross-complementing rodent repair deficiency, complementation group 3
NP_001123812.1
786 aa
ercc3,  D.rerio
excision repair cross-complementing rodent repair deficiency, complementation group 3
NP_963876.1
782 aa
hay,  D.melanogaster
haywire
NP_524020.2
798 aa
AgaP_AGAP012169,  A.gambiae
AgaP_AGAP012169
XP_320364.4
812 aa
Y66D12A.15,  C.elegans
Y66D12A.15
NP_499487.1
789 aa
SSL2,  S.cerevisiae
SSL2
NP_012123.1
843 aa
KLLA0E13025g,  K.lactis
KLLA0E13025g
XP_454537.1
858 aa
AGOS_AFR280W,  E.gossypii
AGOS_AFR280W
NP_985827.1
830 aa
ptr8,  S.pombe
ptr8
NP_593474.1
804 aa
MGG_06470,  M.oryzae
MGG_06470
XP_003717094.1
835 aa
NCU06438,  N.crassa
NCU06438
XP_957329.1
862 aa
XPB1,  A.thaliana
XPB1
NP_568592.1
767 aa
XPB2,  A.thaliana
XPB2
NP_568591.1
766 aa
Os01g0691600,  O.sativa
Os01g0691600
NP_001043936.1
580 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

D.melanogaster
The original allele, haync2, is homozygous male sterile; some derivative alleles are recessive lethal. Homozygous haync2 males display defects in meiosis, flagellar elongation and nuclear shaping. haync2 also male sterile in transheterozygotes with recessive male-sterile alleles of β Tub85D or with wrl1 suggesting a role for the haywire product in microtubule function. Deficiencies of hay are fertile in heterozygous combination with the above interacting mutations, indicating that the extragenic failure haync2 to complement is based on a poison product mechanism. (See FlyBase for complete description.)

H.sapiens
Trichothiodystrophy.
Xeroderma pigmentosum, group B.



Publications
Articles associated with genes and sequences of this homology group.




Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Helicase_C_3 (pfam13625)
  Helicase conserved C-terminal domain.
HELICc (cd00079)
  Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
Helicase_C_3 (pfam13625)
  Helicase conserved C-terminal domain.
DEXDc (cl17251)
  DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Ercc3 includes H.sapiens ERCC3 and R.norvegicus Ercc3.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (18 transcripts, 15 species)
Actinopterygii - bony fishes (15 transcripts, 8 species)
Ascidiacea - tunicates (3 transcripts, 2 species)
Amniota - vertebrates (2 transcripts, 1 species)
Aves - birds (2 transcripts, 2 species)
Cephalochordata - lancelets (2 transcripts, 1 species)
Amphibia - amphibians (2 transcripts, 2 species)

Arthropoda
Insecta - insects (9 transcripts, 8 species)
Arachnida - arachnids (2 transcripts, 2 species)
Branchiopoda - crustaceans (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Cnidaria
Anthozoa - anthozoans (2 transcripts, 1 species)
Hydrozoa - hydrozoans (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (2 transcripts, 2 species)
Turbellaria - flatworms (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (2 transcripts, 2 species)

Nematoda
Chromadorea - nematodes (2 transcripts, 2 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

Streptophyta
Eudicotyledons - eudicots (33 transcripts, 25 species)
Liliopsida - monocots (12 transcripts, 9 species)
Coniferopsida - conifers (2 transcripts, 2 species)
Bryopsida - mosses (1 transcript, 1 species)

Ascomycota
Sordariomycetes - ascomycetes (3 transcripts, 3 species)
Eurotiomycetes - ascomycetes (1 transcript, 1 species)
Pezizomycetes - ascomycetes (1 transcript, 1 species)

Basidiomycota
Heterobasidiomycetes - basidiomycetes (1 transcript, 1 species)

Bacillariophyta
Bacillariophyceae - diatoms (1 transcript, 1 species)

Oomycetes
Peronosporales - oomycetes (1 transcript, 1 species)

Apicomplexa
Coccidia - apicomplexans (1 transcript, 1 species)

Ciliophora
Oligohymenophorea - ciliates (1 transcript, 1 species)

Dictyosteliida
Dictyostelium - cellular slime molds (1 transcript, 1 species)

Codonosigidae
Monosiga - choanoflagellates (1 transcript, 1 species)

 

 

 

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