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HomoloGene:954. Gene conserved in Tetrapoda Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

CD40,  H.sapiens
CD40 molecule, TNF receptor superfamily member 5
NP_001241.1
277 aa
CD40,  P.troglodytes
CD40 molecule, TNF receptor superfamily member 5
XP_003317038.2
136 aa
CD40,  M.mulatta
CD40 molecule, TNF receptor superfamily member 5
XP_001104333.1
278 aa
CD40,  C.lupus
CD40 molecule, TNF receptor superfamily member 5
NP_001002982.1
274 aa
CD40,  B.taurus
CD40 molecule, TNF receptor superfamily member 5
NP_001099081.1
280 aa
Cd40,  M.musculus
CD40 antigen
NP_035741.2
289 aa
Cd40,  R.norvegicus
CD40 molecule, TNF receptor superfamily member 5
NP_599187.1
289 aa
CD40,  G.gallus
CD40 molecule, TNF receptor superfamily member 5
NP_989996.1
276 aa
cd40,  X.tropicalis
CD40 molecule, TNF receptor superfamily member 5
NP_001138688.1
279 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Immunodeficiency with hyper-IgM, type 3.



Publications
Articles associated with genes and sequences of this homology group.

CD40 ligation reverses T cell tolerance in acute myeloid leukemia.
Zhang L, et al. J Clin Invest 123, 1999-2010 (2013).
Association of SNPs of CD40 gene with multiple sclerosis in Russians.
Sokolova EA, et al. PLoS One 8, e61032 (2013).
[The first results of a combined all-Russian study on clinical genetics of multiple sclerosis].
Sokolova EA, et al. Zh Nevrol Psikhiatr Im S S Korsakova 113, 6-9 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
TNFR (cd00185)
  Tumor necrosis factor receptor (TNFR) domain; superfamily of TNF-like receptor domains. When bound to TNF-like cytokines, TNFRs trigger multiple signal transduction pathways, they are involved in inflammation response, apoptosis, autoimmunity and ...
TNFR (cl12111)
  Tumor necrosis factor receptor (TNFR) domain; superfamily of TNF-like receptor domains. When bound to TNF-like cytokines, TNFRs trigger multiple signal transduction pathways, they are involved in inflammation response, apoptosis, autoimmunity and ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Cd40 includes H.sapiens CD40 and R.norvegicus Cd40.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (7 transcripts, 7 species)
Aves - birds (1 transcript, 1 species)

 

 

 

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