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HomoloGene:7889. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

PIK3R1,  H.sapiens
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
NP_852664.1
724 aa
PIK3R1,  P.troglodytes
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
XP_517729.2
724 aa
PIK3R1,  M.mulatta
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
XP_001089423.1
724 aa
PIK3R1,  C.lupus
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
XP_850341.1
725 aa
PIK3R1,  B.taurus
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
NP_777000.1
724 aa
Pik3r1,  M.musculus
phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)
NP_001070963.1
724 aa
Pik3r1,  R.norvegicus
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
NP_037137.1
724 aa
PIK3R1,  G.gallus
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
XP_424759.1
724 aa
pik3r1,  X.tropicalis
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
XP_002934232.1
722 aa
pik3r1,  D.rerio
phosphoinositide-3-kinase, regulatory subunit 1 (p85 alpha)
XP_683819.3
727 aa
aap-1,  C.elegans
aap-1
NP_491522.1
522 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
???.



Publications
Articles associated with genes and sequences of this homology group.

Mutations in PIK3R1 cause SHORT syndrome.
Dyment DA, et al. Am J Hum Genet 93, 158-66 (2013).
PIK3R1 mutations cause syndromic insulin resistance with lipoatrophy.
Thauvin-Robinet C, et al. Am J Hum Genet 93, 141-9 (2013).
Somatic mutations of PIK3R1 promote gliomagenesis.
Quayle SN, et al. PLoS One 7, e49466 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
iSH2_PI3K_IA_R (cl17108)
  Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits.
SH2 (cl15255)
  Src homology 2 (SH2) domain.
RhoGAP (cl02570)
  RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
SH2 (cl15255)
  Src homology 2 (SH2) domain.
SH3 (cl17036)
  Src Homology 3 domain superfamily.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Pik3r1 includes H.sapiens PIK3R1 and R.norvegicus Pik3r1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Actinopterygii - bony fishes (27 transcripts, 10 species)
Mammalia - mammals (23 transcripts, 15 species)
Aves - birds (4 transcripts, 2 species)
Amphibia - amphibians (4 transcripts, 2 species)
Amniota - vertebrates (2 transcripts, 1 species)
Ascidiacea - tunicates (2 transcripts, 2 species)

Arthropoda
Insecta - insects (5 transcripts, 4 species)
Arachnida - arachnids (1 transcript, 1 species)

Annelida
Polychaeta - segmented worms (2 transcripts, 1 species)

Cnidaria
Anthozoa - anthozoans (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

 

 

 

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