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HomoloGene:77719. Gene conserved in Bilateria Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

RGS11,  H.sapiens
regulator of G-protein signaling 11
467 aa
RGS11,  P.troglodytes
regulator of G-protein signaling 11
597 aa
RGS11,  M.mulatta
regulator of G-protein signaling 11
446 aa
RGS11,  C.lupus
regulator of G-protein signaling 11
465 aa
RGS11,  B.taurus
regulator of G-protein signaling 11
465 aa
Rgs11,  M.musculus
regulator of G-protein signaling 11
466 aa
Rgs11,  R.norvegicus
regulator of G-protein signaling 11
467 aa
RGS11,  G.gallus
regulator of G-protein signaling 11
473 aa
rgs9,  X.tropicalis
regulator of G-protein signaling 9
469 aa
rgs11,  D.rerio
regulator of G-protein signaling 11
359 aa
AgaP_AGAP000232,  A.gambiae
1282 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Articles associated with genes and sequences of this homology group.

RGS7 and -11 complexes accelerate the ON-bipolar cell light response.
Zhang J, et al. Invest Ophthalmol Vis Sci 51, 1121-9 (2010).
Functional redundancy of R7 RGS proteins in ON-bipolar cell dendrites.
Chen FS, et al. Invest Ophthalmol Vis Sci 51, 686-93 (2010).
RGS11 interacts preferentially with R7BP over Galpha(oa)--characterization of Gbeta5-free RGS11.
Saleem Y & Kim KS. Biochem Biophys Res Commun 386, 65-70 (2009).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
GGL (cl00069)
  G protein gamma subunit-like motifs, the alpha-helical G-gamma chain dimerizes with the G-beta propeller subunit as part of the heterotrimeric G-protein complex; involved in signal transduction via G-protein-coupled receptors.
DEP (cl02442)
  DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is ...
RGS (cl02565)
  Regulator of G protein signaling (RGS) domain superfamily.

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Rgs11 includes H.sapiens RGS11 and R.norvegicus Rgs11.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (10 transcripts, 9 species)
Actinopterygii - bony fishes (3 transcripts, 3 species)
Aves - birds (3 transcripts, 1 species)
Amphibia - amphibians (3 transcripts, 2 species)

Insecta - insects (1 transcript, 1 species)

Hirudinida - segmented worms (1 transcript, 1 species)




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