HomoloGene

HomoloGene:77068. Gene conserved in Bilateria

Genes Genes identified as putative homologs of one another during the construction of HomoloGene.		Proteins Proteins used in sequence comparisons and their conserved domain architectures.
	GIPC3, H.sapiens GIPC PDZ domain containing family, member 3		NP_573568.1 312 aa
	GIPC3, P.troglodytes GIPC PDZ domain containing family, member 3		XP_001135295.1 305 aa
	GIPC3, M.mulatta GIPC PDZ domain containing family, member 3		XP_001100669.1 312 aa
	GIPC3, C.lupus GIPC PDZ domain containing family, member 3		XP_542175.2 316 aa
	GIPC3, B.taurus GIPC PDZ domain containing family, member 3		NP_001193223.1 318 aa
	Gipc3, M.musculus GIPC PDZ domain containing family, member 3		NP_683753.1 297 aa
	Gipc3, R.norvegicus GIPC PDZ domain containing family, member 3		NP_001102752.1 297 aa
	LOC100857667, G.gallus PDZ domain-containing protein GIPC3-like		XP_004948770.1 372 aa
	gipc3, X.tropicalis GIPC PDZ domain containing family, member 3		NP_001096502.1 318 aa
	zgc:136839, D.rerio zgc:136839		NP_001038783.1 333 aa
	kermit, D.melanogaster kermit		NP_652028.1 336 aa
	AgaP_AGAP007674, A.gambiae AgaP_AGAP007674		XP_001687864.1 342 aa

Protein Alignments

Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST

Regenerate Alignments

Phenotypes Phenotypic information for the genes in this entry imported from model organism databases.
*H.sapiens*
MIM:601869 ???.

Publications Articles associated with genes and sequences of this homology group.
Homozygosity mapping identifies a novel GIPC3 mutation causing congenital nonsyndromic hearing loss in a Saudi family. Ramzan K, et al. Gene 521, 195-9 (2013).
The autosomal recessive nonsyndromic deafness locus DFNB72 is located on chromosome 19p13.3. Ain Q, et al. Hum Genet 122, 445-50 (2007).
Molecular cloning and characterization of mouse Gipc3. Saitoh T, et al. Int J Mol Med 9, 251-6 (2002).
Molecular cloning and characterization of human GIPC3, a novel gene homologous to human GIPC1 and GIPC2. Saitoh T, et al. Int J Oncol 20, 577-82 (2002).
New gene for autosomal recessive non-syndromic hearing loss maps to either chromosome 3q or 19p. Chen A, et al. Am J Med Genet 71, 467-71 (1997).
Mutations of GIPC3 cause nonsyndromic hearing loss DFNB72 but not DFNB81 that also maps to chromosome 19p. Rehman AU, et al. Hum Genet 130, 759-65 (2011).
Gipc3 mutations associated with audiogenic seizures and sensorineural hearing loss in mouse and human. Charizopoulou N, et al. Nat Commun 2, 201 (2011).
dGIPC is required for the locomotive activity and longevity in Drosophila. Kim J, et al. Biochem Biophys Res Commun 402, 565-70 (2010).
Drosophila melanogaster lipins are tissue-regulated and developmentally regulated and present specific subcellular distributions. Valente V, et al. FEBS J 277, 4775-88 (2010).
[A new locus for an autosomal dominant, non-syndromic hearing impairment (DFNA57) located on chromosome 19p13.2 and overlapping with DFNB15]. Bönsch D, et al. HNO 56, 177-82 (2008).
See all (22)

Conserved Domains Conserved Domains from CDD found in protein sequences by rpsblast searching.
PDZ (cl00117) PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...

Related Homology Resources Links to curated and computed homology information found in other databases.
MGI:2387006 Orthology group for M.musculus Gipc3 includes H.sapiens GIPC3 and R.norvegicus Gipc3.

UniGene Links to UniGene entries found by comparing the homologous proteins against the transcript database.
*Arthropoda*
Insecta - insects (12 transcripts, 10 species)
Malacostraca - crustaceans (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)
*Chordata*
Mammalia - mammals (5 transcripts, 5 species)
Actinopterygii - bony fishes (2 transcripts, 2 species)
Amphibia - amphibians (1 transcript, 1 species)
*Platyhelminthes*
Trematoda - flatworms (2 transcripts, 2 species)
Turbellaria - flatworms (1 transcript, 1 species)
*Cnidaria*
Anthozoa - anthozoans (2 transcripts, 1 species)
*Nematoda*
Chromadorea - nematodes (2 transcripts, 1 species)
*Annelida*
Hirudinida - segmented worms (1 transcript, 1 species)
*Codonosigidae*
Monosiga - choanoflagellates (2 transcripts, 1 species)
*Streptophyta*
Eudicotyledons - eudicots (1 transcript, 1 species)

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