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HomoloGene:68268. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

PGD,  H.sapiens
phosphogluconate dehydrogenase
NP_002622.2
483 aa
PGD,  P.troglodytes
phosphogluconate dehydrogenase
XP_003307850.1
482 aa
PGD,  C.lupus
phosphogluconate dehydrogenase
XP_535411.2
483 aa
PGD,  B.taurus
phosphogluconate dehydrogenase
NP_001137210.1
483 aa
Pgd,  M.musculus
phosphogluconate dehydrogenase
NP_001074743.1
483 aa
LOC100360180,  R.norvegicus
6-phosphogluconate dehydrogenase, decarboxylating-like
XP_002729611.1
483 aa
PGD,  G.gallus
phosphogluconate dehydrogenase
NP_001006303.1
483 aa
pgd,  X.tropicalis
phosphogluconate dehydrogenase
XP_002939602.2
482 aa
pgd,  D.rerio
phosphogluconate hydrogenase
NP_998618.1
511 aa
Pgd,  D.melanogaster
Phosphogluconate dehydrogenase
NP_476860.2
481 aa
AgaP_AGAP004197,  A.gambiae
AgaP_AGAP004197
XP_313091.4
482 aa
T25B9.9,  C.elegans
T25B9.9
NP_501998.1
484 aa
GND2,  S.cerevisiae
GND2
NP_011772.3
492 aa
GND1,  S.cerevisiae
GND1
NP_012053.3
489 aa
KLLA0A09339g,  K.lactis
KLLA0A09339g
XP_451408.1
492 aa
AGOS_AFR129W,  E.gossypii
AGOS_AFR129W
NP_985676.2
498 aa
SPBC660.16,  S.pombe
SPBC660.16
NP_595095.1
492 aa
MGG_00175,  M.oryzae
MGG_00175
XP_003718951.1
492 aa
NCU03100,  N.crassa
NCU03100
XP_964959.1
523 aa
AT1G64190,  A.thaliana
AT1G64190
NP_176601.1
487 aa
AT5G41670,  A.thaliana
AT5G41670
NP_198982.1
487 aa
Os11g0484500,  O.sativa
Os11g0484500
NP_001067912.1
508 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

D.melanogaster
Structural gene for 6-phosphogluconate dehydrogenase (6PGD), the last enzyme in the oxidative part of the pentose phosphate shunt. The electrophoretic variants PgdA and PgdB have been described in Drosophila (Kazanian, Young and Childs, 1965; Young, 1966), PgdA migrating faster in starch gel than PgdB. PgdA/PgdB heterozygous females produce a hybrid band of intermediate mobility. The enzyme 6PGD is a dimer. Its molecular weight was reported by Kazanian (1966) to be about 79,000; Williamson et al. (See FlyBase for complete description.)



Publications
Articles associated with genes and sequences of this homology group.

Molecular size studies on 6-phosphogluconate dehydrogenase.
Kazazian HH Jr. Nature 212, 197-8 (1966).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
gnd (TIGR00873)
  6-phosphogluconate dehydrogenase (decarboxylating).
6PGD (pfam00393)
  6-phosphogluconate dehydrogenase, C-terminal domain.
PRK09287 (PRK09287)
  6-phosphogluconate dehydrogenase; Validated.
NADB_Rossmann (cl09931)
  Rossmann-fold NAD(P)(+)-binding proteins.
6PGD (pfam00393)
  6-phosphogluconate dehydrogenase, C-terminal domain.
F420_oxidored (cl19126)
  NADP oxidoreductase coenzyme F420-dependent.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Pgd includes H.sapiens PGD and R.norvegicus Pgd.


 

 

 

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