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HomoloGene

Discover Homologs

HomoloGene:62795. Gene conserved in Tetrapoda

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Genes Genes identified as putative homologs of one another during the construction of HomoloGene.			Proteins Proteins used in sequence comparisons and their conserved domain architectures.
	TTBK2, H.sapiens tau tubulin kinase 2			NP_775771.3 1244 aa
	TTBK2, P.troglodytes tau tubulin kinase 2			XP_001155340.1 1244 aa
	TTBK2, M.mulatta tau tubulin kinase 2			XP_002804790.1 1229 aa
	TTBK2, C.lupus tau tubulin kinase 2			XP_005638372.1 1244 aa
	TTBK2, B.taurus tau tubulin kinase 2			NP_001193000.1 1243 aa
	Ttbk2, M.musculus tau tubulin kinase 2			NP_542966.2 1312 aa
	Ttbk2, R.norvegicus tau tubulin kinase 2			NP_001101236.1 1211 aa
	TTBK2, G.gallus tau tubulin kinase 2			XP_004941717.1 1331 aa
	ttbk2, X.tropicalis tau tubulin kinase 2			NP_001072838.1 1215 aa

Protein Alignments

Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST

Regenerate Alignments

Phenotypes Phenotypic information for the genes in this entry imported from model organism databases.
*H.sapiens*
MIM:604432 Spinocerebellar ataxia-11.

Publications Articles associated with genes and sequences of this homology group.
Upregulation of Na-coupled glucose transporter SGLT1 by Tau tubulin kinase 2. Alesutan I, et al. Cell Physiol Biochem 30, 458-65 (2012).
TTBK2 kinase substrate specificity and the impact of spinocerebellar-ataxia-causing mutations on expression, activity, localization and development. Bouskila M, et al. Biochem J 437, 157-67 (2011).
Spinocerebellar ataxia type 11 (SCA11) is an uncommon cause of dominant ataxia among French and German kindreds. Bauer P, et al. J Neurol Neurosurg Psychiatry 81, 1229-32 (2010).
Spinocerebellar Ataxia Type 11 Houlden H, et al. (1993).
Spinocerebellar ataxia type 11 in the Chinese Han population. Xu Q, et al. Neurol Sci 31, 107-9 (2010).
Missense exchanges in the TTBK2 gene mutated in SCA11. Edener U, et al. J Neurol 256, 1856-9 (2009).
Mutations in TTBK2, encoding a kinase implicated in tau phosphorylation, segregate with spinocerebellar ataxia type 11. Houlden H, et al. Nat Genet 39, 1434-6 (2007).
Expression, purification and crystallization of a human tau-tubulin kinase 2 that phosphorylates tau protein. Kitano-Takahashi M, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun 63, 602-4 (2007).
Tau-tubulin kinase phosphorylates tau at Ser-208 and Ser-210, sites found in paired helical filament-tau. Tomizawa K, et al. FEBS Lett 492, 221-7 (2001).
Autosomal dominant cerebellar ataxia type III: linkage in a large British family to a 7.6-cM region on chromosome 15q14-21.3. Worth PF, et al. Am J Hum Genet 65, 420-6 (1999).
See all (18)

Conserved Domains Conserved Domains from CDD found in protein sequences by rpsblast searching.
PKc_like (cl09925) Protein Kinases, catalytic domain.

Related Homology Resources Links to curated and computed homology information found in other databases.
MGI:2155779 Orthology group for M.musculus Ttbk2 includes H.sapiens TTBK2 and R.norvegicus Ttbk2.

UniGene Links to UniGene entries found by comparing the homologous proteins against the transcript database.
*Chordata*
Mammalia - mammals (9 transcripts, 8 species)
Actinopterygii - bony fishes (4 transcripts, 2 species)
Amphibia - amphibians (1 transcript, 1 species)
*Nematoda*
Chromadorea - nematodes (5 transcripts, 2 species)
*Arthropoda*
Insecta - insects (2 transcripts, 2 species)
*Mollusca*
Gastropoda - gastropods (1 transcript, 1 species)
*Platyhelminthes*
Turbellaria - flatworms (1 transcript, 1 species)

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