Display Settings:

Format

Send to:

Choose Destination
HomoloGene:62795. Gene conserved in Tetrapoda Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

TTBK2,  H.sapiens
tau tubulin kinase 2
NP_775771.3
1244 aa
TTBK2,  P.troglodytes
tau tubulin kinase 2
XP_001155340.1
1244 aa
TTBK2,  M.mulatta
tau tubulin kinase 2
XP_002804790.1
1229 aa
TTBK2,  C.lupus
tau tubulin kinase 2
XP_005638372.1
1244 aa
TTBK2,  B.taurus
tau tubulin kinase 2
NP_001193000.1
1243 aa
Ttbk2,  M.musculus
tau tubulin kinase 2
NP_542966.2
1312 aa
Ttbk2,  R.norvegicus
tau tubulin kinase 2
NP_001101236.1
1211 aa
TTBK2,  G.gallus
tau tubulin kinase 2
XP_004941717.1
1331 aa
ttbk2,  X.tropicalis
tau tubulin kinase 2
NP_001072838.1
1215 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Spinocerebellar ataxia-11.



Publications
Articles associated with genes and sequences of this homology group.

Upregulation of Na-coupled glucose transporter SGLT1 by Tau tubulin kinase 2.
Alesutan I, et al. Cell Physiol Biochem 30, 458-65 (2012).
Spinocerebellar Ataxia Type 11
Houlden H, et al. (1993).
Spinocerebellar ataxia type 11 in the Chinese Han population.
Xu Q, et al. Neurol Sci 31, 107-9 (2010).
Missense exchanges in the TTBK2 gene mutated in SCA11.
Edener U, et al. J Neurol 256, 1856-9 (2009).
Expression, purification and crystallization of a human tau-tubulin kinase 2 that phosphorylates tau protein.
Kitano-Takahashi M, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun 63, 602-4 (2007).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
PKc_like (cl09925)
  Protein Kinases, catalytic domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Ttbk2 includes H.sapiens TTBK2 and R.norvegicus Ttbk2.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (9 transcripts, 8 species)
Actinopterygii - bony fishes (4 transcripts, 2 species)
Amphibia - amphibians (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (5 transcripts, 2 species)

Arthropoda
Insecta - insects (2 transcripts, 2 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Platyhelminthes
Turbellaria - flatworms (1 transcript, 1 species)

 

 

 

Support Center