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HomoloGene:5037. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

PRKDC,  H.sapiens
protein kinase, DNA-activated, catalytic polypeptide
NP_008835.5
4128 aa
PRKDC,  P.troglodytes
protein kinase, DNA-activated, catalytic polypeptide
XP_001147162.1
4128 aa
PRKDC,  M.mulatta
protein kinase, DNA-activated, catalytic polypeptide
XP_001100610.2
4099 aa
PRKDC,  C.lupus
protein kinase, DNA-activated, catalytic polypeptide
NP_001006652.1
4144 aa
PRKDC,  B.taurus
protein kinase, DNA-activated, catalytic polypeptide
NP_001243488.1
4124 aa
Prkdc,  M.musculus
protein kinase, DNA activated, catalytic polypeptide
NP_035289.2
4128 aa
Prkdc,  R.norvegicus
protein kinase, DNA activated, catalytic polypeptide
XP_003751148.1
4126 aa
PRKDC,  G.gallus
protein kinase, DNA-activated, catalytic polypeptide
NP_989989.1
4133 aa
prkdc,  X.tropicalis
protein kinase, DNA-activated, catalytic polypeptide
XP_002934154.2
4146 aa
wu:fa96e12,  D.rerio
wu:fa96e12
XP_001919588.3
4112 aa
AgaP_AGAP003967,  A.gambiae
AgaP_AGAP003967
XP_318419.5
4191 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

PRKDC mutations in a SCID patient with profound neurological abnormalities.
Woodbine L, et al. J Clin Invest 123, 2969-80 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
FATC (pfam02260)
  FATC domain.
FAT (pfam02259)
  FAT domain.
NUC194 (pfam08163)
  NUC194 domain.
COG1747 (COG1747)
  Uncharacterized N-terminal domain of the transcription elongation factor GreA [Function unknown].
FAT (pfam02259)
  FAT domain.
FATC (pfam02260)
  FATC domain.
NUC194 (pfam08163)
  NUC194 domain.
PI3Kc_like (cl00119)
  Phosphoinositide 3-kinase (PI3K)-like family, catalytic domain; The PI3K-like catalytic domain family is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs), ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Prkdc includes H.sapiens PRKDC and R.norvegicus Prkdc.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (19 transcripts, 13 species)
Actinopterygii - bony fishes (8 transcripts, 7 species)
Amniota - vertebrates (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)

Cnidaria
Hydrozoa - hydrozoans (2 transcripts, 1 species)

Annelida
Polychaeta - segmented worms (2 transcripts, 1 species)

Arthropoda
Insecta - insects (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Porifera
Demospongiae - sponges (1 transcript, 1 species)

Streptophyta
Coniferopsida - conifers (1 transcript, 1 species)

 

 

 

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