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HomoloGene:38046. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

PRKAB2,  H.sapiens
protein kinase, AMP-activated, beta 2 non-catalytic subunit
NP_005390.1
272 aa
PRKAB2,  P.troglodytes
protein kinase, AMP-activated, beta 2 non-catalytic subunit
XP_513749.2
272 aa
PRKAB2,  M.mulatta
protein kinase, AMP-activated, beta 2 non-catalytic subunit
XP_001093423.2
270 aa
PRKAB2,  C.lupus
protein kinase, AMP-activated, beta 2 non-catalytic subunit
XP_005630761.1
272 aa
PRKAB2,  B.taurus
protein kinase, AMP-activated, beta 2 non-catalytic subunit
NP_001179257.1
272 aa
Prkab2,  M.musculus
protein kinase, AMP-activated, beta 2 non-catalytic subunit
NP_892042.2
271 aa
Prkab2,  R.norvegicus
protein kinase, AMP-activated, beta 2 non-catalytic subunit
NP_072149.1
271 aa
PRKAB2,  G.gallus
protein kinase, AMP-activated, beta 2 non-catalytic subunit
NP_001038127.1
274 aa
prkab2,  X.tropicalis
protein kinase, AMP-activated, beta 2 non-catalytic subunit
NP_001106572.1
271 aa
prkab2,  D.rerio
protein kinase, AMP-activated, beta 2 non-catalytic subunit
NP_001124105.1
269 aa
aakb-2,  C.elegans
aakb-2
NP_499446.1
274 aa
aakb-1,  C.elegans
aakb-1
NP_510298.1
269 aa
SIP2,  S.cerevisiae
SIP2
NP_011307.1
415 aa
AKINBETA1,  A.thaliana
AKINBETA1
NP_197615.1
283 aa
Os05g0491200,  O.sativa
Os05g0491200
NP_001055908.1
290 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Structural insight into AMPK regulation: ADP comes into play.
Jin X, et al. Structure 15, 1285-95 (2007).
Sumoylation of AMPKβ2 subunit enhances AMP-activated protein kinase activity.
Rubio T, et al. Mol Biol Cell 24, 1801-11, S1-4 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
AMPKBI (pfam04739)
  5'-AMP-activated protein kinase beta subunit, interation domain.
AMPKBI (cl08426)
  5'-AMP-activated protein kinase beta subunit, interation domain.
E_set (cl09101)
  Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Prkab2 includes H.sapiens PRKAB2 and R.norvegicus Prkab2.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (10 transcripts, 10 species)
Actinopterygii - bony fishes (9 transcripts, 9 species)
Ascidiacea - tunicates (2 transcripts, 2 species)
Amphibia - amphibians (2 transcripts, 2 species)
Aves - birds (1 transcript, 1 species)
Hyperoartia - vertebrates (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (4 transcripts, 2 species)
Turbellaria - flatworms (2 transcripts, 1 species)

Arthropoda
Arachnida - arachnids (2 transcripts, 1 species)
Insecta - insects (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (4 transcripts, 2 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Cnidaria
Anthozoa - anthozoans (1 transcript, 1 species)

Streptophyta
Eudicotyledons - eudicots (25 transcripts, 25 species)
Liliopsida - monocots (11 transcripts, 8 species)
Coniferopsida - conifers (3 transcripts, 2 species)

Ascomycota
Sordariomycetes - ascomycetes (3 transcripts, 3 species)
Eurotiomycetes - ascomycetes (1 transcript, 1 species)
Pezizomycetes - ascomycetes (1 transcript, 1 species)

Bacillariophyta
Bacillariophyceae - diatoms (1 transcript, 1 species)

Oomycetes
Peronosporales - oomycetes (1 transcript, 1 species)

 

 

 

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