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HomoloGene:37590. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

IDH2,  H.sapiens
isocitrate dehydrogenase 2 (NADP+), mitochondrial
NP_002159.2
452 aa
IDH2,  P.troglodytes
isocitrate dehydrogenase 2 (NADP+), mitochondrial
XP_510589.2
452 aa
IDH2,  M.mulatta
isocitrate dehydrogenase 2 (NADP+), mitochondrial
XP_002804982.1
475 aa
IDH2,  C.lupus
isocitrate dehydrogenase 2 (NADP+), mitochondrial
XP_005618419.1
422 aa
IDH2,  B.taurus
isocitrate dehydrogenase 2 (NADP+), mitochondrial
NP_786984.1
452 aa
Idh2,  M.musculus
isocitrate dehydrogenase 2 (NADP+), mitochondrial
NP_766599.2
452 aa
Idh2,  R.norvegicus
isocitrate dehydrogenase 2 (NADP+), mitochondrial
NP_001014183.1
452 aa
IDH2,  G.gallus
isocitrate dehydrogenase 2 (NADP+), mitochondrial
NP_001026770.1
452 aa
idh2,  X.tropicalis
isocitrate dehydrogenase 2 (NADP+), mitochondrial
NP_001004799.1
455 aa
idh2,  D.rerio
isocitrate dehydrogenase 2 (NADP+), mitochondrial
NP_955858.1
449 aa
AgaP_AGAP003168,  A.gambiae
AgaP_AGAP003168
XP_312860.5
445 aa
idh-2,  C.elegans
idh-2
NP_509875.1
435 aa
IDP2,  S.cerevisiae
IDP2
NP_013275.1
412 aa
KLLA0F12342g,  K.lactis
KLLA0F12342g
XP_455638.1
415 aa
AGOS_AAL022W,  E.gossypii
AGOS_AAL022W
NP_982520.1
415 aa
ICDH,  A.thaliana
ICDH
NP_175836.1
416 aa
Os01g0248400,  O.sativa
Os01g0248400
NP_001042583.1
414 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
D-2-hydrosyglutaric aciduria 2.



Publications
Articles associated with genes and sequences of this homology group.

Induction of sarcomas by mutant IDH2.
Lu C, et al. Genes Dev 27, 1986-98 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Iso_dh (cl00445)
  Isocitrate/isopropylmalate dehydrogenase.
Iso_dh (cl00445)
  Isocitrate/isopropylmalate dehydrogenase.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Idh2 includes H.sapiens IDH2 and R.norvegicus Idh2.

 

 

 

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