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HomoloGene:3177. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

TGFBR1,  H.sapiens
transforming growth factor, beta receptor 1
NP_004603.1
503 aa
TGFBR1,  P.troglodytes
transforming growth factor, beta receptor 1
XP_001159299.1
503 aa
TGFBR1,  M.mulatta
transforming growth factor, beta receptor 1
XP_001112621.1
503 aa
TGFBR1,  C.lupus
transforming growth factor, beta receptor 1
XP_538750.4
536 aa
TGFBR1,  B.taurus
transforming growth factor, beta receptor 1
NP_777046.1
499 aa
Tgfbr1,  M.musculus
transforming growth factor, beta receptor I
NP_033396.1
503 aa
Tgfbr1,  R.norvegicus
transforming growth factor, beta receptor 1
XP_006238215.1
454 aa
TGFBR1,  G.gallus
transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kDa)
NP_989577.1
503 aa
tgfbr1,  X.tropicalis
transforming growth factor, beta receptor 1
NP_001015961.1
499 aa
tgfbr1a,  D.rerio
transforming growth factor, beta receptor 1 a
NP_001032772.2
500 aa
tgfbr1b,  D.rerio
transforming growth factor, beta receptor 1 b
NP_001108531.1
505 aa
babo,  D.melanogaster
baboon
NP_476999.1
622 aa
AgaP_AGAP012476,  A.gambiae
AgaP_AGAP012476
XP_307671.3
363 aa
AgaP_AGAP008247,  A.gambiae
AgaP_AGAP008247
XP_317220.3
359 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Loeys-Dietz syndrome.
Furlong syndrome.
Aortic aneurysm, familial thoracic 5.



Publications
Articles associated with genes and sequences of this homology group.

TGFBR1 mutations associated with Loeys-Dietz syndrome are inactivating.
Cardoso S, et al. J Recept Signal Transduct Res 32, 150-5 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Pkinase (pfam00069)
  Protein kinase domain.
Activin_recp (pfam01064)
  Activin types I and II receptor domain.
TGF_beta_GS (pfam08515)
  Transforming growth factor beta type I GS-motif.
Pkinase (pfam00069)
  Protein kinase domain.
Activin_recp (pfam01064)
  Activin types I and II receptor domain.
DUF4448 (pfam14610)
  Protein of unknown function (DUF4448).
TGF_beta_GS (cl02621)
  This motif is found in the transforming growth factor beta (TGF-beta) type I which regulates cell growth and differentiation. The name of the GS motif comes from its highly conserved GSGSGLP signature in the cytoplasmic juxtamembrane region immediately preceding the protein's kinase domain. Point mutations in the GS motif modify the signaling ability of the type I receptor.
PKc_like (cl09925)
  Protein Kinases, catalytic domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Tgfbr1 includes H.sapiens TGFBR1 and R.norvegicus Tgfbr1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (11 transcripts, 10 species)
Actinopterygii - bony fishes (6 transcripts, 5 species)
Ascidiacea - tunicates (3 transcripts, 2 species)
Amphibia - amphibians (2 transcripts, 2 species)
Aves - birds (1 transcript, 1 species)

Arthropoda
Insecta - insects (5 transcripts, 4 species)
Arachnida - arachnids (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Cnidaria
Hydrozoa - hydrozoans (2 transcripts, 1 species)

Nematoda
Chromadorea - nematodes (2 transcripts, 2 species)

Platyhelminthes
Trematoda - flatworms (2 transcripts, 2 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

 

 

 

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