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HomoloGene:121491. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

PDHA1,  H.sapiens
pyruvate dehydrogenase (lipoamide) alpha 1
NP_001166926.1
397 aa
PDHA1,  P.troglodytes
pyruvate dehydrogenase (lipoamide) alpha 1
NP_001104283.1
390 aa
LOC719277,  M.mulatta
pyruvate dehydrogenase (lipoamide) alpha 1 pseudogene
XP_001113273.2
359 aa
PDHA1,  C.lupus
pyruvate dehydrogenase (lipoamide) alpha 1
XP_003435519.1
397 aa
PDHA1,  B.taurus
pyruvate dehydrogenase (lipoamide) alpha 1
NP_001094516.1
390 aa
Pdha1,  M.musculus
pyruvate dehydrogenase E1 alpha 1
NP_032836.1
390 aa
Pdha1,  R.norvegicus
pyruvate dehydrogenase (lipoamide) alpha 1
NP_001004072.2
390 aa
PDHA1,  G.gallus
pyruvate dehydrogenase (lipoamide) alpha 1
NP_001012562.1
399 aa
pdha1,  X.tropicalis
pyruvate dehydrogenase (lipoamide) alpha 1
NP_001017072.1
395 aa
pdha1b,  D.rerio
pyruvate dehydrogenase (lipoamide) alpha 1b
NP_001002399.1
393 aa
pdha1a,  D.rerio
pyruvate dehydrogenase (lipoamide) alpha 1a
NP_998558.1
393 aa
AgaP_AGAP004786,  A.gambiae
AgaP_AGAP004786
XP_318026.4
397 aa
AgaP_AGAP004773,  A.gambiae
AgaP_AGAP004773
XP_001689086.1
377 aa
pdha-1,  C.elegans
pdha-1
NP_871953.1
414 aa
PDA1,  S.cerevisiae
PDA1
NP_011105.4
420 aa
KLLA0F12001g,  K.lactis
KLLA0F12001g
XP_455624.1
412 aa
AGOS_AGR103W,  E.gossypii
AGOS_AGR103W
NP_986769.1
408 aa
pda1,  S.pombe
pda1
NP_594892.1
409 aa
MGG_06371,  M.oryzae
MGG_06371
XP_003717203.1
416 aa
NCU06482,  N.crassa
NCU06482
XP_957122.1
417 aa
IAR4,  A.thaliana
IAR4
NP_173828.1
393 aa
E1 ALPHA,  A.thaliana
E1 ALPHA
NP_176198.1
389 aa
Os02g0739600,  O.sativa
Os02g0739600
NP_001048068.1
390 aa
Os06g0246500,  O.sativa
Os06g0246500
NP_001057281.1
398 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Leigh syndrome, X-linked.
Pyruvate dehydrogenase deficiency.
pyruvate decarboxylase deficiency.



Publications
Articles associated with genes and sequences of this homology group.

ß-Cell-specific pyruvate dehydrogenase deficiency impairs glucose-stimulated insulin secretion.
Srinivasan M, et al. Am J Physiol Endocrinol Metab 299, E910-7 (2010).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
TPP_enzymes (cl01629)
  Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Pdha1 includes H.sapiens PDHA1 and R.norvegicus Pdha1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Streptophyta
Eudicotyledons - eudicots (55 transcripts, 34 species)
Liliopsida - monocots (20 transcripts, 9 species)
Bryopsida - mosses (3 transcripts, 1 species)
Coniferopsida - conifers (3 transcripts, 3 species)
Isoetopsida - club-mosses (2 transcripts, 1 species)

Chlorophyta
Chlorophyceae - green algae (2 transcripts, 2 species)

Chordata
Actinopterygii - bony fishes (26 transcripts, 11 species)
Mammalia - mammals (19 transcripts, 16 species)
Ascidiacea - tunicates (3 transcripts, 3 species)
Aves - birds (3 transcripts, 3 species)
Amphibia - amphibians (3 transcripts, 2 species)
Cephalochordata - lancelets (2 transcripts, 1 species)
Amniota - vertebrates (1 transcript, 1 species)
Hyperoartia - vertebrates (1 transcript, 1 species)

Arthropoda
Insecta - insects (9 transcripts, 8 species)
Malacostraca - crustaceans (1 transcript, 1 species)

Porifera
Demospongiae - sponges (4 transcripts, 1 species)

Platyhelminthes
Trematoda - flatworms (3 transcripts, 2 species)
Turbellaria - flatworms (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (2 transcripts, 1 species)

Echinodermata
Echinoidea - sea urchins (2 transcripts, 2 species)

Cnidaria
Hydrozoa - hydrozoans (1 transcript, 1 species)

Oomycetes
Peronosporales - oomycetes (3 transcripts, 1 species)
Pythiales - oomycetes (2 transcripts, 1 species)

Bacillariophyta
Bacillariophyceae - diatoms (2 transcripts, 1 species)

Ciliophora
Oligohymenophorea - ciliates (4 transcripts, 2 species)

Basidiomycota
Heterobasidiomycetes - basidiomycetes (1 transcript, 1 species)

 

 

 

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