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HomoloGene:1119. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

FLNA,  H.sapiens
filamin A, alpha
NP_001104026.1
2647 aa
FLNA,  M.mulatta
filamin A, alpha
XP_001091073.1
2647 aa
FLNA,  C.lupus
filamin A, alpha
XP_867483.1
2646 aa
FLNA,  B.taurus
filamin A, alpha
NP_001193443.1
2647 aa
Flna,  M.musculus
filamin, alpha
NP_034357.2
2639 aa
Flna,  R.norvegicus
filamin A, alpha
NP_001128071.1
2639 aa
FLNA,  G.gallus
filamin A, alpha
NP_989905.1
2610 aa
cher,  D.melanogaster
cheerio
NP_001262658.1
2429 aa
AgaP_AGAP004335,  A.gambiae
AgaP_AGAP004335
XP_313613.5
2488 aa
fln-1,  C.elegans
fln-1
NP_001023550.2
2255 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Heterotopia, periventricular.
Heterotopia, periventricular nodular, with frontometaphyseal dysplasia.
Heterotopia, periventricular, ED variant.
Frontometaphyseal dysplasia.
Otopalatodigital syndrome, type II.
Melnick-Needles syndrome.
Otopalatodigital syndrome, type I.



Publications
Articles associated with genes and sequences of this homology group.

Novel no-stop FLNA mutation causes multi-organ involvement in males.
Oegema R, et al. Am J Med Genet A 161A, 2376-84 (2013).
Heterogeneity of platelet functional alterations in patients with filamin A mutations.
Berrou E, et al. Arterioscler Thromb Vasc Biol 33, e11-8 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
CH (cl00030)
  Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
Filamin (cl19759)
  Filamin/ABP280 repeat.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Flna includes H.sapiens FLNA and R.norvegicus Flna.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (14 transcripts, 11 species)
Actinopterygii - bony fishes (5 transcripts, 4 species)
Amniota - vertebrates (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)
Cephalochordata - lancelets (1 transcript, 1 species)
Hyperoartia - vertebrates (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Platyhelminthes
Turbellaria - flatworms (1 transcript, 1 species)

 

 

 

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