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HomoloGene:111880. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

ARFGEF2,  H.sapiens
ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
NP_006411.2
1785 aa
ARFGEF2,  P.troglodytes
ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
XP_001165517.2
1782 aa
ARFGEF2,  M.mulatta
ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
XP_002798173.1
1743 aa
ARFGEF2,  C.lupus
ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
XP_534448.1
1785 aa
ARFGEF2,  B.taurus
ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
NP_001192581.1
1779 aa
Arfgef2,  M.musculus
ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
NP_001078964.1
1792 aa
Arfgef2,  R.norvegicus
ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
NP_851597.2
1791 aa
ARFGEF2,  G.gallus
ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
XP_417388.3
1792 aa
arfgef2,  X.tropicalis
ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
XP_002933226.2
1792 aa
arfgef2,  D.rerio
ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
XP_002666513.2
1846 aa
sec71,  S.pombe
sec71
NP_594954.1
1811 aa
AT4G38200,  A.thaliana
AT4G38200
NP_195533.2
1687 aa
AT4G35380,  A.thaliana
AT4G35380
NP_195264.2
1706 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Periventricular heterotopia with microcephaly.



Publications
Articles associated with genes and sequences of this homology group.




Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
DUF1981 (pfam09324)
  Domain of unknown function (DUF1981).
CRM1_C (cl07396)
  CRM1 C terminal.
Sec7_N (pfam12783)
  Guanine nucleotide exchange factor in Golgi transport N-terminal.
Sec7_N (pfam12783)
  Guanine nucleotide exchange factor in Golgi transport N-terminal.
Sec7 (cl00136)
  Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Arfgef2 includes H.sapiens ARFGEF2 and R.norvegicus Arfgef2.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (15 transcripts, 10 species)
Actinopterygii - bony fishes (13 transcripts, 5 species)
Amphibia - amphibians (3 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Ascidiacea - tunicates (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (1 transcript, 1 species)
Turbellaria - flatworms (1 transcript, 1 species)

Cnidaria
Anthozoa - anthozoans (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

Streptophyta
Eudicotyledons - eudicots (11 transcripts, 8 species)
Liliopsida - monocots (7 transcripts, 5 species)

Dictyosteliida
Dictyostelium - cellular slime molds (1 transcript, 1 species)

Codonosigidae
Monosiga - choanoflagellates (1 transcript, 1 species)

 

 

 

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