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HomoloGene:105435. Gene conserved in Euteleostomi Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

STX4,  H.sapiens
syntaxin 4
297 aa
STX4,  P.troglodytes
syntaxin 4
281 aa
LOC704880,  M.mulatta
133 aa
STX4,  C.lupus
syntaxin 4
297 aa
STX4,  B.taurus
syntaxin 4
297 aa
Stx4a,  M.musculus
syntaxin 4A (placental)
298 aa
Stx4,  R.norvegicus
syntaxin 4
298 aa
stx4,  D.rerio
syntaxin 4
297 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Articles associated with genes and sequences of this homology group.

Syntaxin-4 is implicated in the secretion of antibodies by human plasma cells.
Gómez-Jaramillo L, et al. J Leukoc Biol 95, 305-12 (2014).
The impact of extracellular syntaxin4 on HaCaT keratinocyte behavior.
Kadono N, et al. Biochem Biophys Res Commun 417, 1200-5 (2012).
Syntaxin 4 heterozygous knockout mice develop muscle insulin resistance.
Yang C, et al. J Clin Invest 107, 1311-8 (2001).
Syntaxin-4 is essential for IgE secretion by plasma cells.
Rahman A, et al. Biochem Biophys Res Commun 440, 163-7 (2013).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
SynN (cd00179)
  Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may ...
t_SNARE (cl00152)
  Soluble NSF (N-ethylmaleimide-sensitive fusion protein)-Attachment protein (SNAP) REceptor domain; these alpha-helical motifs form twisted and parallel heterotetrameric helix bundles; the core complex contains one helix from a protein that is anchored in ...

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Stx4a includes H.sapiens STX4 and R.norvegicus Stx4.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (16 transcripts, 13 species)
Actinopterygii - bony fishes (7 transcripts, 6 species)
Amphibia - amphibians (2 transcripts, 1 species)
Amniota - vertebrates (1 transcript, 1 species)




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