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HomoloGene:101538. Gene conserved in Opisthokonta Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

RAB4A,  H.sapiens
RAB4A, member RAS oncogene family
NP_004569.2
218 aa
RAB4A,  M.mulatta
RAB4A, member RAS oncogene family
XP_001082985.1
218 aa
RAB4A,  C.lupus
RAB4A, member RAS oncogene family
XP_005618898.1
218 aa
RAB4A,  B.taurus
RAB4A, member RAS oncogene family
NP_001033774.1
218 aa
Rab4a,  M.musculus
RAB4A, member RAS oncogene family
NP_033029.2
218 aa
Rab4a,  R.norvegicus
RAB4A, member RAS oncogene family
NP_037151.2
218 aa
RAB4A,  G.gallus
RAB4A, member RAS oncogene family
XP_419573.1
218 aa
rab4a,  D.rerio
RAB4a, member RAS oncogene family
NP_001119853.1
213 aa
ypt4,  S.pombe
ypt4
NP_594796.1
234 aa
MGG_01179,  M.oryzae
MGG_01179
XP_003714063.1
335 aa
NCU00889,  N.crassa
NCU00889
XP_964805.2
349 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Cargo-mediated regulation of a rapid Rab4-dependent recycling pathway.
Yudowski GA, et al. Mol Biol Cell 20, 2774-84 (2009).
Rab4 GTP/GDP modulates amiloride-sensitive sodium channel (ENaC) function in colonic epithelia.
Saxena SK, et al. Biochem Biophys Res Commun 340, 726-33 (2006).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
P-loop_NTPase (cl09099)
  P-loop containing Nucleoside Triphosphate Hydrolases.
Ras_like_GTPase (cl17170)
  Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases).



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Rab4a includes H.sapiens RAB4A and R.norvegicus Rab4a.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (15 transcripts, 12 species)
Actinopterygii - bony fishes (8 transcripts, 7 species)
Aves - birds (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)

Platyhelminthes
Turbellaria - flatworms (3 transcripts, 1 species)
Trematoda - flatworms (2 transcripts, 2 species)

 

 

 

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