GTR Home > Tests > Onco microarray for CLL

Overview

Test name

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Onco microarray for CLL

Purpose of the test

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This is a clinical test intended for Help: Diagnosis, Prognostic, Recurrence, Risk Assessment

Condition

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8 conditions tested. Click Indication tab for more information.

How to order

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For more information, please contact the laboratory directly.

Specimen source

Bone marrow
tumor biopsy
Peripheral (whole) blood

Methodology

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Molecular Genetics
DDeletion/duplication analysis
Microarray
  • Agilent SureSelect
  • Agilent SurePrint G3 Human CGH Microarray Kit, 2x400K
HDetection of homozygosity
Microarray
  • Agilent SureSelect
  • Agilent SurePrint G3 Human CGH Microarray Kit, 2x400K

Summary of what is tested

16 genes and variants, 7 chromosomal regions. Click Methodology tab for more information.

Genes

  • Gene: AKT1 (14q32.33)
  • Gene: ALK (2p23.2-23.1)
  • Gene: ATM (11q22.3)
  • Gene: BCL10 (1p22.3)
  • Gene: BCL11A (2p16.1)
  • Gene: BCL2 (18q21.33)
  • Gene: BCL3 (19q13.32)
  • Gene: BCL6 (3q27.3)
  • Gene: CCND1 (11q13.3)
  • Gene: FGF2 (4q28.1)
  • Gene: IGH (14q32.33)
  • Gene: ITK (5q33.3)
  • Gene: MYB (6q23.3)
  • Gene: MYBL1 (8q13.1)
  • Gene: MYC (8q24.21)
  • Gene: TP53 (17p13.1)

Chromosomal regions/Mitochondria

  • 11q22.3 (ATM)
  • 12p13
  • 13q14.3
  • Chromosomal gains, losses, deletions, and markers
  • homozygosity detection
  • partial trisomy 12
  • trisomy 12

Clinical utility

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Guidance for management

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Establish or confirm diagnosis

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Clinical validity

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Not provided

Testing strategy

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Copy number analysis by aCGH to identyfy alterations in genes involved in lymphoid differentiation, proliferation, cell cycle and to provide important diagnostic and prognostic information that is routinely used in risk stratification for treatment. 000 For more information, please contact the laboratory directly.

IMPORTANT NOTE: NIH does not independently verify information submitted to the GTR; it relies on submitters to provide information that is accurate and not misleading. NIH makes no endorsements of tests or laboratories listed in the GTR. GTR is not a substitute for medical advice. Patients and consumers with specific questions about a genetic test should contact a health care provider or a genetics professional.

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