GTR Home > Tests > Atypical hemolytic uremic syndrome panel

Overview

Test order codeHelp: 5202

Test name

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Atypical hemolytic uremic syndrome panel

Purpose of the test

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This is a clinical test intended for Help: Diagnosis

Condition

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1 condition tested. Click Indication tab for more information.

Methodology

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Molecular Genetics
DDeletion/duplication analysis
Multiplex Ligation-dependent Probe Amplification (MLPA)
CSequence analysis of the entire coding region
Next-Generation (NGS)/Massively parallel sequencing (MPS)

Summary of what is tested

13 genes and variants. Click Methodology tab for more information.

Genes

Clinical validity

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This panel test will provide the likelihood of clinical outcome for tested individuals, and it is primarily determined by the quality of clinical features used to select affected individuals suggested for genetic testing. The likelihood of clinical outcome is affected not only by the presence of the gene mutation in any of the panel genes itself but also by any other modifying factors that might affect the penetrance of the mutation (e.g., the mutation carrier's environmental exposures or personal behaviors) or by the presence or absence of mutations in other genes related to the disease. For this reason, the clinical validity of this particular genetic test for a specific mutation may vary in different populations. For the molecular diagnostic of the disease caused by mutations in any of the panel genes, Centogene is offering hotspot testing, including mutations specific for various world populations, full gene sequencing and deletion/duplication testing for all genes included in the panel, enabling identification of all previously reported mutations, as well as possible detection of other genetical changes.

Citations

Not provided

Clinical utility

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Establish or confirm diagnosis

Citations
  • The results of this multi-gene test are clearly giving the information that can be used to develop a clinical intervention. In addition, this panel test provides clinically useful information that can inform patients and help them making choices that could improve health outcomes. The quality of life of individuals with inherited disorders can be improved by knowledge of genetic predisposition, and gene test for this disease can encourage lifestyle choices that improve long-term health outcomes. The consequences of genetic tests often include social and psychological effects for the patient and his or her family that also need support and attention. This reaffirms the importance of geneticists and genetic counselors as well as primary care practitioners, and their role in informing patients and conveying test results clearly. Centogene has the growing team of genetic experts, genetic counselors and clinical experts, highly trained professionals who offer health solutions tailored to cu

How to order

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Order URL Help: https://www.centogene.com/ordering/how-to-order-a-test.html

Test services

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  • Clinical Testing/Confirmation of Mutations Identified Previously
  • Custom Deletion/Duplication Testing
  • Custom Sequence Analysis
  • Custom Prenatal Testing
  • Custom mutation-specific/Carrier testing

Practice guidelines

IMPORTANT NOTE: NIH does not independently verify information submitted to the GTR; it relies on submitters to provide information that is accurate and not misleading. NIH makes no endorsements of tests or laboratories listed in the GTR. GTR is not a substitute for medical advice. Patients and consumers with specific questions about a genetic test should contact a health care provider or a genetics professional.

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