GTR Home > Tests > Pan Cardiomyopathy Panel (62 Genes)

Overview

Test order codeHelp: lmPCM-pnlAv3_L

Test name

Help

Pan Cardiomyopathy Panel (62 Genes) (PCM Panel)

Purpose of the test

Help

This is a clinical test intended for Help: Diagnosis

Condition

Help

103 conditions tested. Click Indication tab for more information.

Methodology

Help
Molecular Genetics
DDeletion/duplication analysis
VisCap analysis
CSequence analysis of the entire coding region
Next-Generation (NGS)/Massively parallel sequencing (MPS)
  • Illumina HiSeq

Summary of what is tested

61 genes and variants. Click Methodology tab for more information.

Genes

Clinical validity

Help

The detection rate of the Pan Cardiomyopathy Panel is approximately 35% for HCM, ~37% for DCM and ~50% for ARVC. The detection rate for the other cardiomyopathies remains unknown.

Citations
  • The landscape of genetic variation in dilated cardiomyopathy as surveyed by clinical DNA sequencing. - PubMed ID: 24503780
  • Results of clinical genetic testing of 2,912 probands with hypertrophic cardiomyopathy: expanded panels offer limited additional sensitivity. - PubMed ID: 25611685

Clinical utility

Help

Not provided

Testing strategy

Help

Inherited cardiomyopathies are a group of genetically heterogeneous cardiac diseases with a relatively high population frequency, association with sudden cardiac death, and substantial genetic component. Familial inheritance is common and typically follows an autosomal dominant pattern, though all other forms of inheritance exist. The predominant forms are hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM), followed by arrhythmogenic cardiomyopathy and left ventricular non-compaction (LVNC).

How to order

Help

Order URL Help: http://personalizedmedicine.partners.org/Laboratory-For-Molecular-Medicine/Ordering/Cardiomyopathy/PanCardiomyopathy-Panel.aspx

Test services

Help
  • Clinical Testing/Confirmation of Mutations Identified Previously

IMPORTANT NOTE: NIH does not independently verify information submitted to the GTR; it relies on submitters to provide information that is accurate and not misleading. NIH makes no endorsements of tests or laboratories listed in the GTR. GTR is not a substitute for medical advice. Patients and consumers with specific questions about a genetic test should contact a health care provider or a genetics professional.

Support Center