GTR Home > Tests > UGT1A1 Gene Polymorphism (TA Repeat)

Overview

Test order codeHelp: 7064

Test name

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UGT1A1 Gene Polymorphism (TA Repeat)

Purpose of the test

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This is a clinical test intended for Help: Diagnosis, Monitoring, Mutation Confirmation, Pre-symptomatic, Risk Assessment, Screening

Condition

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1 condition tested. Click Indication tab for more information.

Methodology

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Molecular Genetics
TTargeted variant analysis
Bi-directional Sanger Sequence Analysis
  • Applied Biosystems 310 capillary sequencing instrument

Summary of what is tested

1 genes and variants. Click Methodology tab for more information.

Genes

Clinical validity

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Not provided

Clinical utility

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Guidance for selecting a drug therapy and/or dose

Citations
  • UGT1A1*28 polymorphism as a determinant of irinotecan disposition and toxicity. - PubMed ID: 11990381

How to order

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Specimen type: Whole blood with anticoagulant EDTA (3-6mL). Send blood samples at room temperature. blood samples can be preserved at 2-8°C before shipping, but for no longer than one week. Do not freeze the blood. DNA sample: 3 ug of DNA(100-250 ng/µL) in TE, AE or sterile water. Send DNA samples at room temperature. To avoid sample loss and contamination, please use 2.0mL screw cap tubes, or wrap de caps of each microtube with parafilm. The A260/280 ratio should be 1.8-2.0. SNa sample should run on an agarose gel as a single band, showing no degradation, alongside with a quantitative DNA marker.
Order URL Help: http://www.cibic.com.ar/pacientes/consulta-de-analisis

Test services

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  • Clinical Testing/Confirmation of Mutations Identified Previously, Order code: 7064

Clinical resources

Practice guidelines

  • NACB, 2010
    National Academy of Clinical Biochemistry, Clinical practice considerations. In: Laboratory medicine practice guidelines: guidelines and recommendations for laboratory analysis and application of pharmacogenetics to clinical practice, 2010

Consumer resources

IMPORTANT NOTE: NIH does not independently verify information submitted to the GTR; it relies on submitters to provide information that is accurate and not misleading. NIH makes no endorsements of tests or laboratories listed in the GTR. GTR is not a substitute for medical advice. Patients and consumers with specific questions about a genetic test should contact a health care provider or a genetics professional.

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