GTR Home > Genes

CD81 CD81 molecule

Also known as: S5.7; CVID6; TAPA1; TSPAN28

Summary

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. This protein appears to promote muscle cell fusion and support myotube maintenance. Also it may be involved in signal transduction. This gene is localized in the tumor-suppressor gene region and thus it is a candidate gene for malignancies. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

Associated conditions

See all available tests in GTR for this gene

DescriptionTests
Common variable immunodeficiency 6
MedGen: C3150741OMIM: 613496GeneReviews: Not available
See labs

Genomic context

Location:
11p15.5
Sequence:
Chromosome: 11; NC_000011.10 (2376177..2397419)
Total number of exons:
11

Links

IMPORTANT NOTE: NIH does not independently verify information submitted to the GTR; it relies on submitters to provide information that is accurate and not misleading. NIH makes no endorsements of tests or laboratories listed in the GTR. GTR is not a substitute for medical advice. Patients and consumers with specific questions about a genetic test should contact a health care provider or a genetics professional.

Support Center