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BCL10 B cell CLL/lymphoma 10

Also known as: CLAP; mE10; CIPER; IMD37; c-E10; CARMEN

Summary

This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

Associated conditions

See all available tests in GTR for this gene

DescriptionTests
Follicular lymphoma 1
MedGen: C2751665OMIM: 613024GeneReviews: Not available
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Gastric lymphoma
MedGen: C1850900OMIM: 137245GeneReviews: Not available
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Immunodeficiency 37
MedGen: C4015195OMIM: 616098GeneReviews: Not available
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Malignant lymphoma, non-Hodgkin
MedGen: C0024305OMIM: 605027GeneReviews: Not available
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Malignant tumor of testis
MedGen: C0153594OMIM: 273300GeneReviews: Not available
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Mesothelioma, malignant
MedGen: C0345967OMIM: 156240GeneReviews: Not available
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Genomic context

Location:
1p22.3
Sequence:
Chromosome: 1; NC_000001.11 (85265776..85276904, complement)
Total number of exons:
5

Links

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