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RNASEH2B ribonuclease H2 subunit B

Also known as: AGS2; DLEU8

Summary

RNase H2 is composed of a single catalytic subunit (A) and two non-catalytic subunits (B and C) and specifically degrades the RNA of RNA:DNA hybrids. The protein encoded by this gene is the non-catalytic B subunit of RNase H2, which is thought to play a role in DNA replication. Multiple transcript variants encoding different isoforms have been found for this gene. Defects in this gene are a cause of Aicardi-Goutieres syndrome type 2 (AGS2). [provided by RefSeq, Nov 2008]

Genomic context

Location:
13q14.3
Sequence:
Chromosome: 13; NC_000013.11 (50909678..50970462)
Total number of exons:
17

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