TRIO trio Rho guanine nucleotide exchange factor
Gene ID: 7204, updated on 5-Mar-2024Gene type: protein coding
Also known as: tgat; MEBAS; MRD44; MRD63; ARHGEF23
- See all available tests in GTR for this gene
- Go to complete Gene record for TRIO
- Go to Variation Viewer for TRIO variants
Summary
This gene encodes a large protein that functions as a GDP to GTP exchange factor. This protein promotes the reorganization of the actin cytoskeleton, thereby playing a role in cell migration and growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Associated conditions
See all available tests in GTR for this gene
Description | Tests |
---|---|
A genome-wide association study of chemotherapy-induced alopecia in breast cancer patients. GeneReviews: Not available | |
Genome-wide association study identifies ephrin type A receptors implicated in paclitaxel induced peripheral sensory neuropathy. GeneReviews: Not available | |
Intellectual developmental disorder, autosomal dominant 63, with macrocephaly | See labs |
Micrognathia-recurrent infections-behavioral abnormalities-mild intellectual disability syndrome | See labs |
Copy number response
Description |
---|
Copy number response Triplosensitivity No evidence available (Last evaluated 2018-01-24) ClinGen Genome Curation PageHaploinsufficency Sufficient evidence for dosage pathogenicity (Last evaluated 2018-01-24) ClinGen Genome Curation PagePubMed |
Genomic context
- Location:
- 5p15.2
- Sequence:
- Chromosome: 5; NC_000005.10 (14143342..14510204)
- Total number of exons:
- 61
Variation
Resource | Links for this gene |
---|---|
ClinVar | Variants reported to ClinVar |
dbVar | Studies and variants |
SNP | GeneView ReportGo to Variation Viewer for TRIO variants |
1000 Genomes | See 1000 Genomes Browser (GRCh37.p13) |
- BioSystemsBioSystems
- ClinVarRelated medical variations
- dbVarLink from Gene to dbVar
- MedGenRelated information in MedGen
- OMIMLink to related OMIM entry
- PubMed (OMIM)Gene links to PubMed derived from omim_pubmed_cited links
- RefSeq RNAsLink to Nucleotide RefSeq RNAs
- RefSeqGeneLink to Nucleotide RefSeqGenes
- SNP: GeneViewSNPs linked from GeneView
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