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TNNC1 troponin C1, slow skeletal and cardiac type

Gene ID: 7134, updated on 21-Mar-2023
Gene type: protein coding
Also known as: TNC; TN-C; TNNC; CMD1Z; CMH13


Troponin is a central regulatory protein of striated muscle contraction, and together with tropomyosin, is located on the actin filament. Troponin consists of 3 subunits: TnI, which is the inhibitor of actomyosin ATPase; TnT, which contains the binding site for tropomyosin; and TnC, the protein encoded by this gene. The binding of calcium to TnC abolishes the inhibitory action of TnI, thus allowing the interaction of actin with myosin, the hydrolysis of ATP, and the generation of tension. Mutations in this gene are associated with cardiomyopathy dilated type 1Z. [provided by RefSeq, Oct 2008]

Associated conditions

See all available tests in GTR for this gene

Dilated cardiomyopathy 1Z
MedGen: C2678475OMIM: 611879GeneReviews: Not available
See labs
Genome-wide association analysis identifies 13 new risk loci for schizophrenia.
GeneReviews: Not available
Hypertrophic cardiomyopathy 13
MedGen: C2750472OMIM: 613243GeneReviews: Not available
See labs
Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4.
GeneReviews: Not available

Genomic context

Chromosome: 3; NC_000003.12 (52451100..52454041, complement)
Total number of exons:


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