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TNF tumor necrosis factor

Also known as: DIF; TNFA; TNFSF2; TNLG1F; TNF-alpha

Summary

This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine. [provided by RefSeq, Jul 2008]

Associated conditions

See all available tests in GTR for this gene

DescriptionTests
Asthma, susceptibility to
MedGen: C1869116OMIM: 600807GeneReviews: Not available
See labs
Migraine
MedGen: C0149931OMIM: 157300GeneReviews: Not available
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Susceptibility to malaria
MedGen: C1970028OMIM: 611162GeneReviews: Not available
See labs

Genomic context

Location:
6p21.33
Sequence:
Chromosome: 6; NC_000006.12 (31575567..31578336)
Total number of exons:
4

Links

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