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CCL2 C-C motif chemokine ligand 2

Also known as: HC11; MCAF; MCP1; MCP-1; SCYA2; GDCF-2; SMC-CF; HSMCR30

Summary

This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Chemokines are a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of N-terminal cysteine residues of the mature peptide. This chemokine is a member of the CC subfamily which is characterized by two adjacent cysteine residues. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4. [provided by RefSeq, Jul 2013]

Associated conditions

See all available tests in GTR for this gene

DescriptionTests
Human immunodeficiency virus type 1, susceptibility to
MedGen: C1836230OMIM: 609423GeneReviews: Not available
See labs
Mycobacterium tuberculosis, susceptibility to
MedGen: C1834752OMIM: 607948GeneReviews: Not available
See labs
Neural tube defect
MedGen: C0027794OMIM: 182940GeneReviews: Not available
See labs

Genomic context

Location:
17q12
Sequence:
Chromosome: 17; NC_000017.11 (34255277..34257203)
Total number of exons:
3

Links

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