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RARA retinoic acid receptor alpha

Also known as: RAR; NR1B1

Summary

This gene represents a nuclear retinoic acid receptor. The encoded protein, retinoic acid receptor alpha, regulates transcription in a ligand-dependent manner. This gene has been implicated in regulation of development, differentiation, apoptosis, granulopoeisis, and transcription of clock genes. Translocations between this locus and several other loci have been associated with acute promyelocytic leukemia. Alternatively spliced transcript variants have been found for this locus.[provided by RefSeq, Sep 2010]

Associated conditions

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DescriptionTests
Acute promyelocytic leukemia
MedGen: C0023487OMIM: 612376GeneReviews: Not available
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Genomic context

Location:
17q21.2
Sequence:
Chromosome: 17; NC_000017.11 (40309171..40357643)
Total number of exons:
17

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