GTR Home > Genes

GP6 glycoprotein VI platelet

Gene ID: 51206, updated on 12-Aug-2018
Also known as: GPIV; GPVI; BDPLT11

Summary

This gene encodes a platelet membrane glycoprotein of the immunoglobulin superfamily. The encoded protein is a receptor for collagen and plays a critical role in collagen-induced platelet aggregation and thrombus formation. The encoded protein forms a complex with the Fc receptor gamma-chain that initiates the platelet activation signaling cascade upon collagen binding. Mutations in this gene are a cause of platelet-type bleeding disorder-11 (BDPLT11). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]

Associated conditions

See all available tests in GTR for this gene

DescriptionTests
Platelet-type bleeding disorder 11
MedGen: C3280120OMIM: 614201GeneReviews: Not available
See labs

Genomic context

Location:
19q13.42
Sequence:
Chromosome: 19; NC_000019.10 (55013705..55038264, complement)
Total number of exons:
8

Links

IMPORTANT NOTE: NIH does not independently verify information submitted to the GTR; it relies on submitters to provide information that is accurate and not misleading. NIH makes no endorsements of tests or laboratories listed in the GTR. GTR is not a substitute for medical advice. Patients and consumers with specific questions about a genetic test should contact a health care provider or a genetics professional.

Support Center