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EPCAM epithelial cell adhesion molecule

Gene ID: 4072, updated on 27-Jan-2020
Also known as: ESA; KSA; M4S1; MK-1; DIAR5; EGP-2; EGP40; KS1/4; MIC18; TROP1; EGP314; HNPCC8; TACSTD1

Summary

This gene encodes a carcinoma-associated antigen and is a member of a family that includes at least two type I membrane proteins. This antigen is expressed on most normal epithelial cells and gastrointestinal carcinomas and functions as a homotypic calcium-independent cell adhesion molecule. The antigen is being used as a target for immunotherapy treatment of human carcinomas. Mutations in this gene result in congenital tufting enteropathy. [provided by RefSeq, Dec 2008]

Genomic context

Location:
2p21
Sequence:
Chromosome: 2; NC_000002.12 (47369311..47387020)
Total number of exons:
9

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