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LPL lipoprotein lipase

Also known as: LIPD; HDLCQ11

Summary

LPL encodes lipoprotein lipase, which is expressed in heart, muscle, and adipose tissue. LPL functions as a homodimer, and has the dual functions of triglyceride hydrolase and ligand/bridging factor for receptor-mediated lipoprotein uptake. Severe mutations that cause LPL deficiency result in type I hyperlipoproteinemia, while less extreme mutations in LPL are linked to many disorders of lipoprotein metabolism. [provided by RefSeq, Jul 2008]

Genomic context

Location:
8p21.3
Sequence:
Chromosome: 8; NC_000008.11 (19939071..19967259)
Total number of exons:
10

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