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IL2RA interleukin 2 receptor subunit alpha

Also known as: p55; CD25; IL2R; IMD41; TCGFR; IDDM10

Summary

The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency.[provided by RefSeq, Nov 2009]

Genomic context

Location:
10p15.1
Sequence:
Chromosome: 10; NC_000010.11 (6010694..6062370, complement)
Total number of exons:
8

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