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IBSP integrin binding sialoprotein

Gene ID: 3381, updated on 8-Jul-2021
Gene type: protein coding
Also known as: BSP; BNSP; SP-II; BSP-II


The protein encoded by this gene is a major structural protein of the bone matrix. It constitutes approximately 12% of the noncollagenous proteins in human bone and is synthesized by skeletal-associated cell types, including hypertrophic chondrocytes, osteoblasts, osteocytes, and osteoclasts. The only extraskeletal site of its synthesis is the trophoblast. This protein binds to calcium and hydroxyapatite via its acidic amino acid clusters, and mediates cell attachment through an RGD sequence that recognizes the vitronectin receptor. [provided by RefSeq, Jul 2008]

Associated conditions

See all available tests in GTR for this gene

Genome-wide association study using extreme truncate selection identifies novel genes affecting bone mineral density and fracture risk.
GeneReviews: Not available
GWAS of dental caries patterns in the permanent dentition.
GeneReviews: Not available

Genomic context

Chromosome: 4; NC_000004.12 (87799554..87812435)
Total number of exons:


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