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IFNL3 interferon lambda 3

Gene ID: 282617, updated on 18-Nov-2018
Also known as: IL28B; IL28C; IL-28B; IL-28C; IFN-lambda-3; IFN-lambda-4


This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28A (IL28A), and interleukin 29 (IL29) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA). [provided by RefSeq, Jul 2008]

Associated conditions

See all available tests in GTR for this gene

Hepatitis c virus, susceptibility to
MedGen: C1835407OMIM: 609532GeneReviews: Not available
See labs
Peginterferon alfa-2a response
MedGen: CN184128GeneReviews: Not available
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Peginterferon alfa-2b response
MedGen: CN078000GeneReviews: Not available
See labs
Ribavirin response
MedGen: CN184129GeneReviews: Not available
not available
Simeprevir response
MedGen: CN236396GeneReviews: Not available
not available
Telaprevir response
MedGen: CN078014GeneReviews: Not available
not available

Genomic context

Chromosome: 19; NC_000019.10 (39243606..39245077, complement)
Total number of exons:


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