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FOXP1 forkhead box P1

Also known as: MFH; QRF1; 12CC4; hFKH1B; HSPC215

Summary

This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Forkhead box P1 protein contains both DNA-binding- and protein-protein binding-domains. This gene may act as a tumor suppressor as it is lost in several tumor types and maps to a chromosomal region (3p14.1) reported to contain a tumor suppressor gene(s). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Copy number response

Description
Copy number response
Triplosensitivity

No evidence available (Last evaluated (2013-04-11)

ClinGen Genome Curation Page
Haploinsufficency

Sufficient evidence for dosage pathogenicity (Last evaluated (2013-04-11)

ClinGen Genome Curation PagePubMed

Genomic context

Location:
3p13
Sequence:
Chromosome: 3; NC_000003.12 (70954714..71583989, complement)
Total number of exons:
32

Links

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