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U2AF2 U2 small nuclear RNA auxiliary factor 2

Gene ID: 11338, updated on 25-Nov-2021
Gene type: protein coding
Also known as: U2AF65

Summary

U2 auxiliary factor (U2AF), comprised of a large and a small subunit, is a non-snRNP protein required for the binding of U2 snRNP to the pre-mRNA branch site. This gene encodes the U2AF large subunit which contains a sequence-specific RNA-binding region with 3 RNA recognition motifs and an Arg/Ser-rich domain necessary for splicing. The large subunit binds to the polypyrimidine tract of introns early during spliceosome assembly. Multiple transcript variants have been detected for this gene, but the full-length natures of only two have been determined to date. [provided by RefSeq, Jul 2008]

Genomic context

Location:
19q13.42
Sequence:
Chromosome: 19; NC_000019.10 (55654132..55674716)
Total number of exons:
14

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