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G3BP1 G3BP stress granule assembly factor 1

Gene ID: 10146, updated on 28-Nov-2021
Gene type: protein coding
Also known as: G3BP; HDH-VIII

Summary

This gene encodes one of the DNA-unwinding enzymes which prefers partially unwound 3'-tailed substrates and can also unwind partial RNA/DNA and RNA/RNA duplexes in an ATP-dependent fashion. This enzyme is a member of the heterogeneous nuclear RNA-binding proteins and is also an element of the Ras signal transduction pathway. It binds specifically to the Ras-GTPase-activating protein by associating with its SH3 domain. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]

Associated conditions

See all available tests in GTR for this gene

DescriptionTests
A genome-wide association meta-analysis of preschool internalizing problems.
GeneReviews: Not available

Genomic context

Location:
5q33.1
Sequence:
Chromosome: 5; NC_000005.10 (151771954..151812785)
Total number of exons:
12

Links

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