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HOTAIR HOX transcript antisense RNA

Also known as: HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072

Summary

This gene is located within the Homeobox C (HOXC) gene cluster on chromosome 12 and is co-expressed with the HOXC genes. It functions through an RNA product, which binds lysine specific demethylase 1 (LSD1) and Polycomb repressive complex 2 (PRC2), and servers as a scaffold to assemble these regulators at the HOXD gene cluster, thereby promoting epigenetic repression of HOXD. This gene is highly expressed in multiple tumors. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Mar 2017]

Genomic context

Location:
12q13.13
Sequence:
Chromosome: 12; NC_000012.12 (53962308..53974956, complement)
Total number of exons:
7

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