GTR Home > Conditions/Phenotypes > Early-Onset Familial Alzheimer Disease

Summary

Excerpted from the GeneReview: Alzheimer Disease Overview
Alzheimer disease (AD) is characterized by dementia that typically begins with subtle and poorly recognized failure of memory and slowly becomes more severe and, eventually, incapacitating. Other common findings include confusion, poor judgment, language disturbance, agitation, withdrawal, and hallucinations. Occasionally, seizures, Parkinsonian features, increased muscle tone, myoclonus, incontinence, and mutism occur. Death usually results from general inanition, malnutrition, and pneumonia. The typical clinical duration of the disease is eight to ten years, with a range from one to 25 years. Approximately 25% of all AD is familial (i.e., ≥2 persons in a family have AD) of which approximately 95% is late onset (age >60-65 years) and 5% is early onset (age <65 years).

Available tests

8 tests are in the database for this condition.

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Genes See tests for all associated and related genes

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Clinical resources

Practice guidelines

  • ACMG/NSGC, 2011
    Genetic counseling and testing for Alzheimer disease: joint practice guidelines of the American College of Medical Genetics and the National Society of Genetic Counselors.
  • EFNS, 2010
    EFNS guidelines for the diagnosis and management of Alzheimer&apos;s disease.
  • AHRQ, 2010
    Preventing Alzheimer&apos;s disease and cognitive decline.

Consumer resources

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