GTR Home > Conditions/Phenotypes > Atypical hemolytic-uremic syndrome 1

Summary

Excerpted from the GeneReview: Genetic Atypical Hemolytic-Uremic Syndrome
Hemolytic-uremic syndrome (HUS) is characterized by hemolytic anemia, thrombocytopenia, and renal failure caused by platelet thrombi in the microcirculation of the kidney and other organs. The onset of atypical HUS (aHUS) ranges from the neonatal period to adulthood. Genetic aHUS accounts for an estimated 60% of all aHUS. Individuals with genetic aHUS frequently experience relapse even after complete recovery following the presenting episode; 60% of genetic aHUS progresses to end-stage renal disease (ESRD).

Available tests

54 tests are in the database for this condition.

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Genes See tests for all associated and related genes

  • Also known as: AHUS1, AMBP1, ARMD4, ARMS1, CFHL3, FH, FHL1, HF, HF1, HF2, HUS, CFH
    Summary: complement factor H

  • Also known as: CFHL, CFHL1, CFHL1P, CFHR1P, FHR1, H36-1, H36-2, HFL1, HFL2, CFHR1
    Summary: complement factor H related 1

  • Also known as: CFHL3, DOWN16, FHR-3, FHR3, HLF4, CFHR3
    Summary: complement factor H related 3

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