GTR Home > Conditions/Phenotypes > Asthma, susceptibility to

Summary

Bronchial asthma is the most common chronic disease affecting children and young adults. It is a complex genetic disorder with a heterogeneous phenotype, largely attributed to the interactions among many genes and between these genes and the environment. Asthma-related traits include clinical symptoms of asthma, such as coughing, wheezing, and dyspnea; bronchial hyperresponsiveness (BHR) as assessed by methacholine challenge test; serum IgE levels; atopy; and atopic dermatitis (Laitinen et al., 2001; Illig and Wjst, 2002; Pillai et al., 2006). See 147050 for information on the asthma-associated phenotype atopy. [from OMIM]

Genes See tests for all associated and related genes

  • Also known as: ADRB2R, ADRBR, B2AR, BAR, BETA2AR, ADRB2
    Summary: adrenoceptor beta 2

  • Also known as: 5-LO, 5-LOX, 5LPG, LOG5, ALOX5
    Summary: arachidonate 5-lipoxygenase

  • Also known as: SCYA11, CCL11
    Summary: C-C motif chemokine ligand 11

  • Also known as: MHC-G, HLA-G
    Summary: major histocompatibility complex, class I, G

  • Also known as: HMT, HNMT-S1, HNMT-S2, MRT51, HNMT
    Summary: histamine N-methyltransferase

  • Also known as: IL-13, P600, IL13
    Summary: interleukin 13

  • Also known as: MG2, MUC7
    Summary: mucin 7, secreted

  • Also known as: LDL-PLA2, LP-PLA2, PAFAD, PAFAH, PLA2G7
    Summary: phospholipase A2 group VII

  • Also known as: LU103, PNSP1, UGRP1, pnSP-1, SCGB3A2
    Summary: secretoglobin family 3A member 2

  • Also known as: DIF, TNF-alpha, TNFA, TNFSF2, TNLG1F, TNF
    Summary: tumor necrosis factor

Clinical features

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